Tags

Type your tag names separated by a space and hit enter

Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy.
Clin Endocrinol (Oxf). 1990 May; 32(5):583-92.CE

Abstract

The long-term follow-up (greater than or equal to 4 years) of clinical, hormonal and radiological aspects in 22 'cured' prolactinoma patients after adenomectomy was studied. Dynamic secretion of PRL and TSH was also evaluated, in order to identify the persistence of any underlying abnormality of hypothalamic pituitary control and to predict relapses. A relapse into hyperprolactinaemia was shown in 36% of patients 5-90 months (mean 46) after surgery. This was accompanied by reappearance of clinical symptoms but not by the radiological demonstration of the adenoma in any patients. A significant PRL rise after domperidone, a dopaminergic antagonist drug, was shown in cured patients after surgery (mean +/- SEM peak, 2977 +/- 645 mU/l) but this was markedly lower than that observed in control subjects (5732 +/- 440 mU/l). In fact, normal PRL increments were shown in only 6/16 (37%) patients. TSH hyper-responsiveness to domperidone normalized in only 46% of patients. Similar PRL responses to those obtained with domperidone were shown when a TRH test was given. A relapse into hyperprolactinaemia was observed in six of ten (60%) non-responders to domperidone and in four of seven (57%) non-responders to TRH, whereas six normal responders to domperidone and TRH had not relapsed at that time. Plasma PRL levels during pregnancy showed increments lower than those observed in normal pregnant women only in domperidone and TRH non-responder patients. These results indicate that a relapse into hyperprolactinaemia and a blunted PRL rise during pregnancy were present only in patients with persistently reduced PRL response to dynamic tests.

Authors+Show Affiliations

Department of Biomedicine, University of Turin, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2114241

Citation

Ciccarelli, E, et al. "Long-term Follow-up of 'cured' Prolactinoma Patients After Successful Adenomectomy." Clinical Endocrinology, vol. 32, no. 5, 1990, pp. 583-92.
Ciccarelli E, Ghigo E, Miola C, et al. Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy. Clin Endocrinol (Oxf). 1990;32(5):583-92.
Ciccarelli, E., Ghigo, E., Miola, C., Gandini, G., Muller, E. E., & Camanni, F. (1990). Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy. Clinical Endocrinology, 32(5), 583-92.
Ciccarelli E, et al. Long-term Follow-up of 'cured' Prolactinoma Patients After Successful Adenomectomy. Clin Endocrinol (Oxf). 1990;32(5):583-92. PubMed PMID: 2114241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy. AU - Ciccarelli,E, AU - Ghigo,E, AU - Miola,C, AU - Gandini,G, AU - Muller,E E, AU - Camanni,F, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 583 EP - 92 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 32 IS - 5 N2 - The long-term follow-up (greater than or equal to 4 years) of clinical, hormonal and radiological aspects in 22 'cured' prolactinoma patients after adenomectomy was studied. Dynamic secretion of PRL and TSH was also evaluated, in order to identify the persistence of any underlying abnormality of hypothalamic pituitary control and to predict relapses. A relapse into hyperprolactinaemia was shown in 36% of patients 5-90 months (mean 46) after surgery. This was accompanied by reappearance of clinical symptoms but not by the radiological demonstration of the adenoma in any patients. A significant PRL rise after domperidone, a dopaminergic antagonist drug, was shown in cured patients after surgery (mean +/- SEM peak, 2977 +/- 645 mU/l) but this was markedly lower than that observed in control subjects (5732 +/- 440 mU/l). In fact, normal PRL increments were shown in only 6/16 (37%) patients. TSH hyper-responsiveness to domperidone normalized in only 46% of patients. Similar PRL responses to those obtained with domperidone were shown when a TRH test was given. A relapse into hyperprolactinaemia was observed in six of ten (60%) non-responders to domperidone and in four of seven (57%) non-responders to TRH, whereas six normal responders to domperidone and TRH had not relapsed at that time. Plasma PRL levels during pregnancy showed increments lower than those observed in normal pregnant women only in domperidone and TRH non-responder patients. These results indicate that a relapse into hyperprolactinaemia and a blunted PRL rise during pregnancy were present only in patients with persistently reduced PRL response to dynamic tests. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/2114241/Long_term_follow_up_of_'cured'_prolactinoma_patients_after_successful_adenomectomy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1990&volume=32&issue=5&spage=583 DB - PRIME DP - Unbound Medicine ER -