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Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles.
Lipids Health Dis 2010; 9:141LH

Abstract

Acne vulgaris is a common dermatological disorder, one that is frequently associated with depression, anxiety and other psychological sequelae. In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. Emerging studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress. Indeed, there are indications that lipid peroxidation itself is a match that lights an inflammatory cascade in acne. The notion that lipid peroxidation is a 'starter gun' in acne is not a new one; here we review the nearly 50-year-old lipid peroxidation theory and provide a historical perspective to the contemporary investigations and clinical implications.In addition, we present a novel hypothesis in which lipid peroxidation may be priming an increased susceptibility to co-morbid depression and anxiety in those with acne. The emerging research on the systemic burden of oxidative stress in acne sheds further light on the brain-skin axis. The recent findings also suggest potential avenues of approach for the treatment of acne via specific nutrients, dietary modifications, oral and topical interventions.

Authors+Show Affiliations

Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA. wpbowe@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21143923

Citation

Bowe, Whitney P., and Alan C. Logan. "Clinical Implications of Lipid Peroxidation in Acne Vulgaris: Old Wine in New Bottles." Lipids in Health and Disease, vol. 9, 2010, p. 141.
Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids Health Dis. 2010;9:141.
Bowe, W. P., & Logan, A. C. (2010). Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids in Health and Disease, 9, p. 141. doi:10.1186/1476-511X-9-141.
Bowe WP, Logan AC. Clinical Implications of Lipid Peroxidation in Acne Vulgaris: Old Wine in New Bottles. Lipids Health Dis. 2010 Dec 9;9:141. PubMed PMID: 21143923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. AU - Bowe,Whitney P, AU - Logan,Alan C, Y1 - 2010/12/09/ PY - 2010/12/04/received PY - 2010/12/09/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/2/3/medline SP - 141 EP - 141 JF - Lipids in health and disease JO - Lipids Health Dis VL - 9 N2 - Acne vulgaris is a common dermatological disorder, one that is frequently associated with depression, anxiety and other psychological sequelae. In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. Emerging studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress. Indeed, there are indications that lipid peroxidation itself is a match that lights an inflammatory cascade in acne. The notion that lipid peroxidation is a 'starter gun' in acne is not a new one; here we review the nearly 50-year-old lipid peroxidation theory and provide a historical perspective to the contemporary investigations and clinical implications.In addition, we present a novel hypothesis in which lipid peroxidation may be priming an increased susceptibility to co-morbid depression and anxiety in those with acne. The emerging research on the systemic burden of oxidative stress in acne sheds further light on the brain-skin axis. The recent findings also suggest potential avenues of approach for the treatment of acne via specific nutrients, dietary modifications, oral and topical interventions. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/21143923/full_citation/Clinical_implications_of_lipid_peroxidation_in_acne_vulgaris:_old_wine_in_new_bottles_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-141 DB - PRIME DP - Unbound Medicine ER -