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[Long-term malaria prophylaxis with mefloquine: a study of adverse drug reactions].
Therapie. 2010 Sep-Oct; 65(5):439-45.T

Abstract

PURPOSE

To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC).

METHODS

The transversal survey involved all military personnel of the Moroccan contingent and was carried out using a questionnaire to be filled out by a multidisciplinary medical team. It was performed in all the military sites and the advanced posts accessible during the period of the study.

RESULTS

The study involved 362 male military subjects. Ninety-four adverse drug reactions were described: neuropsychiatric (anxiety, irritability, dizziness...) [n=76], digestive (anorexia, diarrhea, nausea...) [n=42], cardiovascular (tachycardia, palpitation, precordialgia...) [n=5], musculoskeletal (arthralgia, cramps) [n=4], cutaneous (redness, purpura) [n=2], and other (n=13). No "unexpected" or "serious" adverse drug reaction was reported. The causality assessment score was determined in 94 cases. Two of these reports were rated "likely", 12 "possible" and 80 doubtful. More adverse drug reactions were reported by subjects having medical and paramedical functions.

CONCLUSION

During our study, mefloquine induced adverse drug reactions in a quarter of the treated subjects. Most of the adverse drug reactions were neuropsychiatric. No "serious" adverse drug reactions were reported underlying the interest of its use, even for long-term chemoprophylaxis.

Authors+Show Affiliations

Laboratoire de Pharmaco-Toxicologie, Faculté de Médecine et de Pharmacie, Rabat, Maroc. eljaoudi_rachid@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

21144479

Citation

El Jaoudi, Rachid, et al. "[Long-term Malaria Prophylaxis With Mefloquine: a Study of Adverse Drug Reactions]." Therapie, vol. 65, no. 5, 2010, pp. 439-45.
El Jaoudi R, Benziane H, Khabbal Y, et al. [Long-term malaria prophylaxis with mefloquine: a study of adverse drug reactions]. Therapie. 2010;65(5):439-45.
El Jaoudi, R., Benziane, H., Khabbal, Y., Elomri, N., Lamsaouri, J., & Cherrah, Y. (2010). [Long-term malaria prophylaxis with mefloquine: a study of adverse drug reactions]. Therapie, 65(5), 439-45. https://doi.org/10.2515/therapie/2010049
El Jaoudi R, et al. [Long-term Malaria Prophylaxis With Mefloquine: a Study of Adverse Drug Reactions]. Therapie. 2010 Sep-Oct;65(5):439-45. PubMed PMID: 21144479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Long-term malaria prophylaxis with mefloquine: a study of adverse drug reactions]. AU - El Jaoudi,Rachid, AU - Benziane,Hamid, AU - Khabbal,Youssef, AU - Elomri,Naoual, AU - Lamsaouri,Jamal, AU - Cherrah,Yahia, Y1 - 2010/12/13/ PY - 2009/03/31/received PY - 2010/07/26/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/4/8/medline SP - 439 EP - 45 JF - Therapie JO - Therapie VL - 65 IS - 5 N2 - PURPOSE: To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC). METHODS: The transversal survey involved all military personnel of the Moroccan contingent and was carried out using a questionnaire to be filled out by a multidisciplinary medical team. It was performed in all the military sites and the advanced posts accessible during the period of the study. RESULTS: The study involved 362 male military subjects. Ninety-four adverse drug reactions were described: neuropsychiatric (anxiety, irritability, dizziness...) [n=76], digestive (anorexia, diarrhea, nausea...) [n=42], cardiovascular (tachycardia, palpitation, precordialgia...) [n=5], musculoskeletal (arthralgia, cramps) [n=4], cutaneous (redness, purpura) [n=2], and other (n=13). No "unexpected" or "serious" adverse drug reaction was reported. The causality assessment score was determined in 94 cases. Two of these reports were rated "likely", 12 "possible" and 80 doubtful. More adverse drug reactions were reported by subjects having medical and paramedical functions. CONCLUSION: During our study, mefloquine induced adverse drug reactions in a quarter of the treated subjects. Most of the adverse drug reactions were neuropsychiatric. No "serious" adverse drug reactions were reported underlying the interest of its use, even for long-term chemoprophylaxis. SN - 0040-5957 UR - https://www.unboundmedicine.com/medline/citation/21144479/[Long_term_malaria_prophylaxis_with_mefloquine:_a_study_of_adverse_drug_reactions]_ L2 - http://publications.edpsciences.org/10.2515/therapie/2010049 DB - PRIME DP - Unbound Medicine ER -