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ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus.
Virology. 2011 Feb 05; 410(1):248-56.V

Abstract

The ORF3 protein of the pathogenic porcine circovirus 2 (PCV2) causes apoptosis of the virus-infected cells. In PCV2-infected piglets, ORF3 induces B and CD4 T lymphocyte depletion and lymphoid organ destruction and the ORF3-deficient PCV2 is attenuated in its pathogenicity (Virology, 383 (2009), 338). In addition to its role in causing the apoptosis of the immune cells, characteristic of the PCV2 infection associated disease conditions, the ORF3 also plays a role in the systemic dissemination of the PCV2 infection. Our experiments here show that ORF3 expedites the spread of the virus by inducing the early release of the virus from the infected cells. Further, in PCV2-infected mice, the ORF3-induced apoptosis also aids in recruiting macrophages to phagocytize the infected apoptotic cells leading to the systemic dissemination of the infection. The apoptotic activity of the ORF3 of PCV2 hence lends advantage to the spread of the virus.

Authors+Show Affiliations

Animal Health Biotechnology Group, Temasek Lifesciences Laboratory, The National University of Singapore, 1 Research Link, Singapore.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21144544

Citation

Karuppannan, Anbu K., and Jimmy Kwang. "ORF3 of Porcine Circovirus 2 Enhances the in Vitro and in Vivo Spread of the of the Virus." Virology, vol. 410, no. 1, 2011, pp. 248-56.
Karuppannan AK, Kwang J. ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus. Virology. 2011;410(1):248-56.
Karuppannan, A. K., & Kwang, J. (2011). ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus. Virology, 410(1), 248-56. https://doi.org/10.1016/j.virol.2010.11.009
Karuppannan AK, Kwang J. ORF3 of Porcine Circovirus 2 Enhances the in Vitro and in Vivo Spread of the of the Virus. Virology. 2011 Feb 5;410(1):248-56. PubMed PMID: 21144544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus. AU - Karuppannan,Anbu K, AU - Kwang,Jimmy, Y1 - 2010/12/08/ PY - 2010/08/16/received PY - 2010/09/10/revised PY - 2010/11/09/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/2/18/medline SP - 248 EP - 56 JF - Virology JO - Virology VL - 410 IS - 1 N2 - The ORF3 protein of the pathogenic porcine circovirus 2 (PCV2) causes apoptosis of the virus-infected cells. In PCV2-infected piglets, ORF3 induces B and CD4 T lymphocyte depletion and lymphoid organ destruction and the ORF3-deficient PCV2 is attenuated in its pathogenicity (Virology, 383 (2009), 338). In addition to its role in causing the apoptosis of the immune cells, characteristic of the PCV2 infection associated disease conditions, the ORF3 also plays a role in the systemic dissemination of the PCV2 infection. Our experiments here show that ORF3 expedites the spread of the virus by inducing the early release of the virus from the infected cells. Further, in PCV2-infected mice, the ORF3-induced apoptosis also aids in recruiting macrophages to phagocytize the infected apoptotic cells leading to the systemic dissemination of the infection. The apoptotic activity of the ORF3 of PCV2 hence lends advantage to the spread of the virus. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/21144544/ORF3_of_porcine_circovirus_2_enhances_the_in_vitro_and_in_vivo_spread_of_the_of_the_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(10)00725-7 DB - PRIME DP - Unbound Medicine ER -