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Statin therapy and cataract in type 2 diabetes.
Diabetes Metab 2011; 37(2):139-43DM

Abstract

BACKGROUND

It was recently reported that the prolonged use of statins may predispose to incident cataract in the general population. Cataract is a frequent comorbidity of diabetes, and statins are widely prescribed in patients with type 2 diabetes (T2D) both for primary and secondary cardiovascular prevention. For this reason, this study aimed to assess whether or not the use of statins was associated with an increased prevalence of cataract in such a high-risk population and, conversely, whether or not there was greater usage of statins, or any other lipid-lowering drugs, in T2D patients with cataract.

PATIENTS AND METHODS

This was a cross-sectional analysis of 780 T2D outpatients, with a mean age (± 1 SD) of 64 ± 12 years and diabetes duration of 13 ± 9 years. Diabetic retinopathy (DR) was found in 23%, and cataract was diagnosed in 16.8% (n=131). Age and diabetes duration of the patients with cataract were significantly higher than those of patients without cataract (n = 649): 75 ± 9 vs 62 ± 11 years, and 20 ± 11 vs 12 ± 8 years, respectively (both P < 0.0001). HbA(1c) was non-significantly higher in the cataract group: 7.75 ± 1.55% vs 7.57 ± 1.49% (NS).

RESULTS

Statins, fibrates and/or ezetimibe use did not differ between patients with and without cataract, nor was cataract prevalence higher in statin users (n=435) vs non-users (n = 345). Statin use in patients with cataract was not higher than in cataract-free subgroups with mean age (n=218) or with both mean age and diabetes duration (n = 161) similar to those of patients with cataract.

CONCLUSION

In this cross-sectional analysis of a large diabetic population at very high risk of both DR and cataract, chronic therapy with statins was not cataractogenic, and the presence of cataract was not associated with more statin or other lipid-lowering drug use. This suggests that the benefits of statin therapy in T2D may far outweigh any potential ocular drawbacks as a side effect which, in any case, were not supported by our findings.

Authors+Show Affiliations

Service d'endocrinologie et nutrition, cliniques universitaires St.-Luc, Bruxelles, Belgium. michel.hermans@diab.ucl.ac.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21145274

Citation

Hermans, M P., et al. "Statin Therapy and Cataract in Type 2 Diabetes." Diabetes & Metabolism, vol. 37, no. 2, 2011, pp. 139-43.
Hermans MP, Ahn SA, Rousseau MF. Statin therapy and cataract in type 2 diabetes. Diabetes Metab. 2011;37(2):139-43.
Hermans, M. P., Ahn, S. A., & Rousseau, M. F. (2011). Statin therapy and cataract in type 2 diabetes. Diabetes & Metabolism, 37(2), pp. 139-43. doi:10.1016/j.diabet.2010.09.005.
Hermans MP, Ahn SA, Rousseau MF. Statin Therapy and Cataract in Type 2 Diabetes. Diabetes Metab. 2011;37(2):139-43. PubMed PMID: 21145274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin therapy and cataract in type 2 diabetes. AU - Hermans,M P, AU - Ahn,S A, AU - Rousseau,M F, Y1 - 2010/12/08/ PY - 2010/06/03/received PY - 2010/09/05/revised PY - 2010/09/06/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/8/13/medline SP - 139 EP - 43 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 37 IS - 2 N2 - BACKGROUND: It was recently reported that the prolonged use of statins may predispose to incident cataract in the general population. Cataract is a frequent comorbidity of diabetes, and statins are widely prescribed in patients with type 2 diabetes (T2D) both for primary and secondary cardiovascular prevention. For this reason, this study aimed to assess whether or not the use of statins was associated with an increased prevalence of cataract in such a high-risk population and, conversely, whether or not there was greater usage of statins, or any other lipid-lowering drugs, in T2D patients with cataract. PATIENTS AND METHODS: This was a cross-sectional analysis of 780 T2D outpatients, with a mean age (± 1 SD) of 64 ± 12 years and diabetes duration of 13 ± 9 years. Diabetic retinopathy (DR) was found in 23%, and cataract was diagnosed in 16.8% (n=131). Age and diabetes duration of the patients with cataract were significantly higher than those of patients without cataract (n = 649): 75 ± 9 vs 62 ± 11 years, and 20 ± 11 vs 12 ± 8 years, respectively (both P < 0.0001). HbA(1c) was non-significantly higher in the cataract group: 7.75 ± 1.55% vs 7.57 ± 1.49% (NS). RESULTS: Statins, fibrates and/or ezetimibe use did not differ between patients with and without cataract, nor was cataract prevalence higher in statin users (n=435) vs non-users (n = 345). Statin use in patients with cataract was not higher than in cataract-free subgroups with mean age (n=218) or with both mean age and diabetes duration (n = 161) similar to those of patients with cataract. CONCLUSION: In this cross-sectional analysis of a large diabetic population at very high risk of both DR and cataract, chronic therapy with statins was not cataractogenic, and the presence of cataract was not associated with more statin or other lipid-lowering drug use. This suggests that the benefits of statin therapy in T2D may far outweigh any potential ocular drawbacks as a side effect which, in any case, were not supported by our findings. SN - 1878-1780 UR - https://www.unboundmedicine.com/medline/citation/21145274/Statin_therapy_and_cataract_in_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1262-3636(10)00230-2 DB - PRIME DP - Unbound Medicine ER -