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Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection.
J Hepatol. 2011 Jul; 55(1):69-75.JH

Abstract

BACKGROUND & AIMS

The probability of response to peginterferon and ribavirin is associated with numerous host and virological factors. Attainment of a rapid virological response (RVR), defined as undetectable HCV RNA at week 4 during treatment with peginterferon and ribavirin, is highly predictive of sustained virological response (SVR). The aim of the present study was to determine the relative importance of the kinetics of antiviral response compared to baseline host and virological factors for predicting SVR.

METHODS

A retrospective analysis of 1383 patients, encompassing genotypes 1-4, treated with peginterferon alfa-2a and ribavirin, was performed. Baseline characteristics were compared across HCV genotypes and pretreatment factors associated with RVR were identified. The relative significance of RVR compared to other baseline factors for predicting SVR was analyzed by multiple logistic regression analysis.

RESULTS

RVR was achieved by 16% of patients with genotype 1 and 71% and 60% of those with genotype 2 and 3, respectively. Among patients who achieved RVR, the rate of SVR was high across all genotypes and ranged from 88% to 100% (genotypes 1-4). Baseline factors predictive of RVR included genotype, younger age, lower initial viral load, higher ALT ratio, absence of advanced fibrosis, and younger age. Notably, the presence of RVR generated the highest odds ratio (5.47, 95% confidence interval 3.97-7.52) for predicting SVR in multiple logistic regression analysis of these factors.

CONCLUSIONS

Attainment of RVR varies by genotype and is associated with several baseline factors. Patients who achieve RVR have the highest rates of SVR, regardless of genotype. These findings have important implications for predicting and managing response-guided combination antiviral therapies.

Authors+Show Affiliations

University of North Carolina, Chapel Hill, NC 27599, USA. mfried@med.unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21145856

Citation

Fried, Michael W., et al. "Rapid Virological Response Is the Most Important Predictor of Sustained Virological Response Across Genotypes in Patients With Chronic Hepatitis C Virus Infection." Journal of Hepatology, vol. 55, no. 1, 2011, pp. 69-75.
Fried MW, Hadziyannis SJ, Shiffman ML, et al. Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. J Hepatol. 2011;55(1):69-75.
Fried, M. W., Hadziyannis, S. J., Shiffman, M. L., Messinger, D., & Zeuzem, S. (2011). Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. Journal of Hepatology, 55(1), 69-75. https://doi.org/10.1016/j.jhep.2010.10.032
Fried MW, et al. Rapid Virological Response Is the Most Important Predictor of Sustained Virological Response Across Genotypes in Patients With Chronic Hepatitis C Virus Infection. J Hepatol. 2011;55(1):69-75. PubMed PMID: 21145856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. AU - Fried,Michael W, AU - Hadziyannis,Stephanos J, AU - Shiffman,Mitchell L, AU - Messinger,Diethelm, AU - Zeuzem,Stefan, Y1 - 2010/11/23/ PY - 2010/06/21/received PY - 2010/10/12/revised PY - 2010/10/18/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/11/9/medline SP - 69 EP - 75 JF - Journal of hepatology JO - J. Hepatol. VL - 55 IS - 1 N2 - BACKGROUND & AIMS: The probability of response to peginterferon and ribavirin is associated with numerous host and virological factors. Attainment of a rapid virological response (RVR), defined as undetectable HCV RNA at week 4 during treatment with peginterferon and ribavirin, is highly predictive of sustained virological response (SVR). The aim of the present study was to determine the relative importance of the kinetics of antiviral response compared to baseline host and virological factors for predicting SVR. METHODS: A retrospective analysis of 1383 patients, encompassing genotypes 1-4, treated with peginterferon alfa-2a and ribavirin, was performed. Baseline characteristics were compared across HCV genotypes and pretreatment factors associated with RVR were identified. The relative significance of RVR compared to other baseline factors for predicting SVR was analyzed by multiple logistic regression analysis. RESULTS: RVR was achieved by 16% of patients with genotype 1 and 71% and 60% of those with genotype 2 and 3, respectively. Among patients who achieved RVR, the rate of SVR was high across all genotypes and ranged from 88% to 100% (genotypes 1-4). Baseline factors predictive of RVR included genotype, younger age, lower initial viral load, higher ALT ratio, absence of advanced fibrosis, and younger age. Notably, the presence of RVR generated the highest odds ratio (5.47, 95% confidence interval 3.97-7.52) for predicting SVR in multiple logistic regression analysis of these factors. CONCLUSIONS: Attainment of RVR varies by genotype and is associated with several baseline factors. Patients who achieve RVR have the highest rates of SVR, regardless of genotype. These findings have important implications for predicting and managing response-guided combination antiviral therapies. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/21145856/Rapid_virological_response_is_the_most_important_predictor_of_sustained_virological_response_across_genotypes_in_patients_with_chronic_hepatitis_C_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(10)01093-7 DB - PRIME DP - Unbound Medicine ER -