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Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study.
Neuroimage 2011; 55(2):644-57N

Abstract

Prefrontal transcranial direct current stimulation (tDCS) with the anode placed on the left dorsolateral prefrontal cortex (DLPFC) has been reported to enhance working memory in healthy subjects and to improve mood in major depression. However, its putative antidepressant, cognitive and behavior action is not well understood. Here, we evaluated the distribution of neuronal electrical activity changes after anodal tDCS of the left DLPFC and cathodal tDCS of the right supraorbital region using spectral power analysis and standardized low resolution tomography (sLORETA). Ten healthy subjects underwent real and sham tDCS on separate days in a double-blind, placebo-controlled cross-over trial. Anodal tDCS was applied for 20 min at 2 mA intensity over the left DLPFC, while the cathode was positioned over the contralateral supraorbital region. After tDCS, EEG was recorded during an eyes-closed resting state followed by a working memory (n-back) task. Statistical non-parametric mapping showed reduced left frontal delta activity in the real tDCS condition. Specifically, a significant reduction of mean current densities (sLORETA) for the delta band was detected in the left subgenual PFC, the anterior cingulate and in the left medial frontal gyrus. Moreover, the effect was strongest for the first 5 min (p<0.01). The following n-back task revealed a positive impact of prefrontal tDCS on error rate, accuracy and reaction time. This was accompanied by increased P2- and P3- event-related potentials (ERP) component-amplitudes for the 2-back condition at the electrode Fz. A source localization using sLORETA for the time window 250-450 ms showed enhanced activity in the left parahippocampal gyrus for the 2-back condition. These results suggest that anodal tDCS of the left DLPFC and/or cathodal tDCS of the contralateral supraorbital region may modulate regional electrical activity in the prefrontal and anterior cingulate cortex in addition to improving working memory performance.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University Munich, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21146614

Citation

Keeser, D, et al. "Prefrontal Direct Current Stimulation Modulates Resting EEG and Event-related Potentials in Healthy Subjects: a Standardized Low Resolution Tomography (sLORETA) Study." NeuroImage, vol. 55, no. 2, 2011, pp. 644-57.
Keeser D, Padberg F, Reisinger E, et al. Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study. Neuroimage. 2011;55(2):644-57.
Keeser, D., Padberg, F., Reisinger, E., Pogarell, O., Kirsch, V., Palm, U., ... Mulert, C. (2011). Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study. NeuroImage, 55(2), pp. 644-57. doi:10.1016/j.neuroimage.2010.12.004.
Keeser D, et al. Prefrontal Direct Current Stimulation Modulates Resting EEG and Event-related Potentials in Healthy Subjects: a Standardized Low Resolution Tomography (sLORETA) Study. Neuroimage. 2011 Mar 15;55(2):644-57. PubMed PMID: 21146614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study. AU - Keeser,D, AU - Padberg,F, AU - Reisinger,E, AU - Pogarell,O, AU - Kirsch,V, AU - Palm,U, AU - Karch,S, AU - Möller,H-J, AU - Nitsche,M A, AU - Mulert,C, Y1 - 2010/12/10/ PY - 2010/07/30/received PY - 2010/11/03/revised PY - 2010/12/02/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/6/11/medline SP - 644 EP - 57 JF - NeuroImage JO - Neuroimage VL - 55 IS - 2 N2 - Prefrontal transcranial direct current stimulation (tDCS) with the anode placed on the left dorsolateral prefrontal cortex (DLPFC) has been reported to enhance working memory in healthy subjects and to improve mood in major depression. However, its putative antidepressant, cognitive and behavior action is not well understood. Here, we evaluated the distribution of neuronal electrical activity changes after anodal tDCS of the left DLPFC and cathodal tDCS of the right supraorbital region using spectral power analysis and standardized low resolution tomography (sLORETA). Ten healthy subjects underwent real and sham tDCS on separate days in a double-blind, placebo-controlled cross-over trial. Anodal tDCS was applied for 20 min at 2 mA intensity over the left DLPFC, while the cathode was positioned over the contralateral supraorbital region. After tDCS, EEG was recorded during an eyes-closed resting state followed by a working memory (n-back) task. Statistical non-parametric mapping showed reduced left frontal delta activity in the real tDCS condition. Specifically, a significant reduction of mean current densities (sLORETA) for the delta band was detected in the left subgenual PFC, the anterior cingulate and in the left medial frontal gyrus. Moreover, the effect was strongest for the first 5 min (p<0.01). The following n-back task revealed a positive impact of prefrontal tDCS on error rate, accuracy and reaction time. This was accompanied by increased P2- and P3- event-related potentials (ERP) component-amplitudes for the 2-back condition at the electrode Fz. A source localization using sLORETA for the time window 250-450 ms showed enhanced activity in the left parahippocampal gyrus for the 2-back condition. These results suggest that anodal tDCS of the left DLPFC and/or cathodal tDCS of the contralateral supraorbital region may modulate regional electrical activity in the prefrontal and anterior cingulate cortex in addition to improving working memory performance. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/21146614/Prefrontal_direct_current_stimulation_modulates_resting_EEG_and_event_related_potentials_in_healthy_subjects:_a_standardized_low_resolution_tomography__sLORETA__study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(10)01585-5 DB - PRIME DP - Unbound Medicine ER -