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The glucocorticoid system is required for the voluntary exercise-induced enhancement of learning and memory in rats.
Behav Brain Res. 2011 May 16; 219(1):75-81.BB

Abstract

Although it is well established that voluntary exercise can improve cognitive functions, the underlying mechanisms are largely unknown. Glucocorticoids play an important role in learning and memory functions. This study addressed whether the glucocorticoid system would play a role in the exercise-induced enhancement of learning and memory. Intact rats or those that were either adrenalectomized or daily given the corticosterone-synthesis inhibitor metyrapone were allowed to freely exercise in a running wheel for 10 days. Control animals were kept sedentary for this period. After this period, they were trained and tested on a water-maze spatial task using three-trial per day for 5 consecutive days, succeeded by a probe trial two days later. Exercise increased plasma corticosterone levels, as assessed after this 10-day period. Both adrenalectomy and metyrapone slightly reduced running-wheel activity. Adrenalectomy reduced the plasma corticosterone levels to almost zero whereas metyrapone selectively blocked the exercise-induced increase in corticosterone levels. Exercise significantly improved performance during both training and retention of the water-maze task whereas this effect was absent in both adrenalectomized and metyrapone-treated rats. These findings indicate that the glucocorticoid system play a crucial role in the beneficial effects of voluntary exercise on cognitive functions in rats.

Authors+Show Affiliations

Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21147170

Citation

Hajisoltani, Razieh, et al. "The Glucocorticoid System Is Required for the Voluntary Exercise-induced Enhancement of Learning and Memory in Rats." Behavioural Brain Research, vol. 219, no. 1, 2011, pp. 75-81.
Hajisoltani R, Rashidy-Pour A, Vafaei AA, et al. The glucocorticoid system is required for the voluntary exercise-induced enhancement of learning and memory in rats. Behav Brain Res. 2011;219(1):75-81.
Hajisoltani, R., Rashidy-Pour, A., Vafaei, A. A., Ghaderdoost, B., Bandegi, A. R., & Motamedi, F. (2011). The glucocorticoid system is required for the voluntary exercise-induced enhancement of learning and memory in rats. Behavioural Brain Research, 219(1), 75-81. https://doi.org/10.1016/j.bbr.2010.12.005
Hajisoltani R, et al. The Glucocorticoid System Is Required for the Voluntary Exercise-induced Enhancement of Learning and Memory in Rats. Behav Brain Res. 2011 May 16;219(1):75-81. PubMed PMID: 21147170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The glucocorticoid system is required for the voluntary exercise-induced enhancement of learning and memory in rats. AU - Hajisoltani,Razieh, AU - Rashidy-Pour,Ali, AU - Vafaei,Abbas A, AU - Ghaderdoost,Behshid, AU - Bandegi,Ahmad Reza, AU - Motamedi,Fereshteh, Y1 - 2010/12/13/ PY - 2010/09/29/received PY - 2010/11/28/revised PY - 2010/12/05/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/7/14/medline SP - 75 EP - 81 JF - Behavioural brain research JO - Behav Brain Res VL - 219 IS - 1 N2 - Although it is well established that voluntary exercise can improve cognitive functions, the underlying mechanisms are largely unknown. Glucocorticoids play an important role in learning and memory functions. This study addressed whether the glucocorticoid system would play a role in the exercise-induced enhancement of learning and memory. Intact rats or those that were either adrenalectomized or daily given the corticosterone-synthesis inhibitor metyrapone were allowed to freely exercise in a running wheel for 10 days. Control animals were kept sedentary for this period. After this period, they were trained and tested on a water-maze spatial task using three-trial per day for 5 consecutive days, succeeded by a probe trial two days later. Exercise increased plasma corticosterone levels, as assessed after this 10-day period. Both adrenalectomy and metyrapone slightly reduced running-wheel activity. Adrenalectomy reduced the plasma corticosterone levels to almost zero whereas metyrapone selectively blocked the exercise-induced increase in corticosterone levels. Exercise significantly improved performance during both training and retention of the water-maze task whereas this effect was absent in both adrenalectomized and metyrapone-treated rats. These findings indicate that the glucocorticoid system play a crucial role in the beneficial effects of voluntary exercise on cognitive functions in rats. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/21147170/The_glucocorticoid_system_is_required_for_the_voluntary_exercise_induced_enhancement_of_learning_and_memory_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00803-X DB - PRIME DP - Unbound Medicine ER -