Tags

Type your tag names separated by a space and hit enter

Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract.
Hum Exp Toxicol. 2011 Jan; 30(1):63-70.HE

Abstract

This inventory evaluates toxicological effects and hepatoprotective potential of Clerodendron glandulosum.Coleb (CG) aqueous extract. Acute and subchronic toxicity tests were performed using Swiss albino mice as per the guideline of Organisation for Economic Cooperation and Development (OECD). Also, hepatoprotective potential of CG extract was examined in experimental model of carbon tetrachloride (CCl(4))-induced hepatotoxicity. Acute and subchronic toxicity tests revealed that CG extract is non-toxic and its median lethal dose (LD(50)) value is >5000 mg/kg bodyweight. Also, rats pretreated with CG extract followed by administration of CCl(4) recorded significant decrement in plasma marker enzymes of hepatic damage, total bilirubin content and hepatic lipid peroxidation. While, hepatic reduced glutathione, ascorbic acid content, activity levels of superoxide and catalase and plasma total protein content were significantly increased. Microscopic examination of liver showed that pretreatment with CG extract prevented CCl(4)-induced hepatic damage in CG + CCl(4) group. CG extract has hepatoprotective potential by modulating activity levels of enzymes and metabolites governing liver function and by helping in maintaining cellular integrity of hepatocytes that is comparable with that of standard drug silymarin. CG extract exhibits potent hepatoprotective activity against CCl(4)-induced hepatic damage but does not exhibit any toxic manifestations.

Links

Publisher Full Text

Authors+Show Affiliations

Jadeja RN
Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat, India.
Thounaojam MC
No affiliation info available
Ansarullah
No affiliation info available
Jadav SV
No affiliation info available
Patel MD
No affiliation info available
Patel DK
No affiliation info available
Salunke SP
No affiliation info available
Padate GS
No affiliation info available
Devkar RV
No affiliation info available
Ramachandran AV
No affiliation info available

MeSH

AnimalsAntioxidantsAscorbic AcidBiomarkersCarbon Tetrachloride PoisoningCatalaseChemical and Drug Induced Liver InjuryClerodendrumGlutathioneLethal Dose 50Lipid PeroxidationMaleMicePhytotherapyPlant ExtractsPlant LeavesRatsRats, WistarSuperoxide DismutaseToxicity Tests

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21148599

Citation

Jadeja, Ravirajsinh N., et al. "Toxicological Evaluation and Hepatoprotective Potential of Clerodendron glandulosum.Coleb Leaf Extract." Human & Experimental Toxicology, vol. 30, no. 1, 2011, pp. 63-70.
Jadeja RN, Thounaojam MC, Ansarullah , et al. Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract. Hum Exp Toxicol. 2011;30(1):63-70.
Jadeja, R. N., Thounaojam, M. C., Ansarullah, ., Jadav, S. V., Patel, M. D., Patel, D. K., Salunke, S. P., Padate, G. S., Devkar, R. V., & Ramachandran, A. V. (2011). Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract. Human & Experimental Toxicology, 30(1), 63-70. https://doi.org/10.1177/0960327110368420
Jadeja RN, et al. Toxicological Evaluation and Hepatoprotective Potential of Clerodendron glandulosum.Coleb Leaf Extract. Hum Exp Toxicol. 2011;30(1):63-70. PubMed PMID: 21148599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract. AU - Jadeja,Ravirajsinh N, AU - Thounaojam,Menaka C, AU - Ansarullah,, AU - Jadav,Snehal V, AU - Patel,Mitul D, AU - Patel,Dipak K, AU - Salunke,Sunita P, AU - Padate,Geeta S, AU - Devkar,Ranjitsinh V, AU - Ramachandran,A V, Y1 - 2010/04/12/ PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/3/25/medline SP - 63 EP - 70 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 30 IS - 1 N2 - This inventory evaluates toxicological effects and hepatoprotective potential of Clerodendron glandulosum.Coleb (CG) aqueous extract. Acute and subchronic toxicity tests were performed using Swiss albino mice as per the guideline of Organisation for Economic Cooperation and Development (OECD). Also, hepatoprotective potential of CG extract was examined in experimental model of carbon tetrachloride (CCl(4))-induced hepatotoxicity. Acute and subchronic toxicity tests revealed that CG extract is non-toxic and its median lethal dose (LD(50)) value is >5000 mg/kg bodyweight. Also, rats pretreated with CG extract followed by administration of CCl(4) recorded significant decrement in plasma marker enzymes of hepatic damage, total bilirubin content and hepatic lipid peroxidation. While, hepatic reduced glutathione, ascorbic acid content, activity levels of superoxide and catalase and plasma total protein content were significantly increased. Microscopic examination of liver showed that pretreatment with CG extract prevented CCl(4)-induced hepatic damage in CG + CCl(4) group. CG extract has hepatoprotective potential by modulating activity levels of enzymes and metabolites governing liver function and by helping in maintaining cellular integrity of hepatocytes that is comparable with that of standard drug silymarin. CG extract exhibits potent hepatoprotective activity against CCl(4)-induced hepatic damage but does not exhibit any toxic manifestations. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/21148599/Toxicological_evaluation_and_hepatoprotective_potential_of_Clerodendron_glandulosum_Coleb_leaf_extract_ L2 - https://journals.sagepub.com/doi/10.1177/0960327110368420?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -