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Intravitreal bevacizumab and cytokine levels in major and macular branch retinal vein occlusion.
Ophthalmologica. 2011; 225(3):150-4.O

Abstract

PURPOSE

My aim was to evaluate the effect of intravitreal bevacizumab and to determine the concentrations of inflammatory cytokines in patients with macular edema due to branch retinal vein occlusion (BRVO), according to the site of the occlusion.

METHODS

In a prospective interventional case series, 46 eyes of patients with macular edema due to major (n = 30) or macular BRVO (n = 16) were included. The patients were treated primarily with intravitreal bevacizumab (1.25 mg/0.05 ml) and completed 12 months of follow-up. Reinjections were performed if optical coherence tomography showed persistent or recurrent macular edema. Aqueous humor samples were collected at the time of initial intravitreal injection. Multiplex bead assays were used for the measurement of cytokines.

RESULTS

The visual acuity and central macular thickness were improved significantly in patients with major and macular BRVO at 12 months. During 12 months, the eyes with major BRVO received a mean of 3.8 intravitreal injections, whereas those with macular BRVO received a mean of 1.9 intravitreal injections (p = 0.009). Significantly increased concentrations of IL-6, IL-8 and MCP-1 were observed in the aqueous humor of BRVO patients compared with control samples. Higher concentrations of IL-6, VEGF, PDGF-AA and MCP-1 were measured in the aqueous humor of patients with major BRVO compared with macular BRVO at baseline (p < 0.05).

CONCLUSION

Intravitreal bevacizumab was similarly effective for improving macular edema in patients with major and macular BRVO. However, macular BRVO required fewer injections and had lower cytokine levels in the aqueous humor than major BRVO.

Authors+Show Affiliations

Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital, Kangwon-don, Republic of Korea. jiwoneye@hallym.or.kr

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21150231

Citation

Lim, Ji Won. "Intravitreal Bevacizumab and Cytokine Levels in Major and Macular Branch Retinal Vein Occlusion." Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, vol. 225, no. 3, 2011, pp. 150-4.
Lim JW. Intravitreal bevacizumab and cytokine levels in major and macular branch retinal vein occlusion. Ophthalmologica. 2011;225(3):150-4.
Lim, J. W. (2011). Intravitreal bevacizumab and cytokine levels in major and macular branch retinal vein occlusion. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, 225(3), 150-4. https://doi.org/10.1159/000322364
Lim JW. Intravitreal Bevacizumab and Cytokine Levels in Major and Macular Branch Retinal Vein Occlusion. Ophthalmologica. 2011;225(3):150-4. PubMed PMID: 21150231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravitreal bevacizumab and cytokine levels in major and macular branch retinal vein occlusion. A1 - Lim,Ji Won, Y1 - 2010/12/09/ PY - 2010/09/10/received PY - 2010/10/18/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/6/28/medline SP - 150 EP - 4 JF - Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde JO - Ophthalmologica VL - 225 IS - 3 N2 - PURPOSE: My aim was to evaluate the effect of intravitreal bevacizumab and to determine the concentrations of inflammatory cytokines in patients with macular edema due to branch retinal vein occlusion (BRVO), according to the site of the occlusion. METHODS: In a prospective interventional case series, 46 eyes of patients with macular edema due to major (n = 30) or macular BRVO (n = 16) were included. The patients were treated primarily with intravitreal bevacizumab (1.25 mg/0.05 ml) and completed 12 months of follow-up. Reinjections were performed if optical coherence tomography showed persistent or recurrent macular edema. Aqueous humor samples were collected at the time of initial intravitreal injection. Multiplex bead assays were used for the measurement of cytokines. RESULTS: The visual acuity and central macular thickness were improved significantly in patients with major and macular BRVO at 12 months. During 12 months, the eyes with major BRVO received a mean of 3.8 intravitreal injections, whereas those with macular BRVO received a mean of 1.9 intravitreal injections (p = 0.009). Significantly increased concentrations of IL-6, IL-8 and MCP-1 were observed in the aqueous humor of BRVO patients compared with control samples. Higher concentrations of IL-6, VEGF, PDGF-AA and MCP-1 were measured in the aqueous humor of patients with major BRVO compared with macular BRVO at baseline (p < 0.05). CONCLUSION: Intravitreal bevacizumab was similarly effective for improving macular edema in patients with major and macular BRVO. However, macular BRVO required fewer injections and had lower cytokine levels in the aqueous humor than major BRVO. SN - 1423-0267 UR - https://www.unboundmedicine.com/medline/citation/21150231/Intravitreal_bevacizumab_and_cytokine_levels_in_major_and_macular_branch_retinal_vein_occlusion_ L2 - https://www.karger.com?DOI=10.1159/000322364 DB - PRIME DP - Unbound Medicine ER -