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Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration.
Cornea. 2011 Jul; 30(7):825-7.C

Abstract

PURPOSE

To report a case of bilateral peripheral corneal thinning with an appearance of Fuchs superficial marginal keratitis in the right eye and Terrien marginal degeneration in the left eye.

METHODS

Interventional case report.

RESULTS

A 28-year-old woman presented with bilateral corneal thinning and a pseudopterygium in the right eye and peripheral corneal thinning in the left eye. Laboratory examinations were negative. Over the next several years, the patient experienced periodic episodes of bilateral ocular redness and discomfort associated with gradual corneal thinning. However, other signs of progression were different in each eye. Pseudopterygium growth was observed in the right eye, consistent with Fuchs superficial marginal keratitis. Progressive lipid deposition at the leading edge of corneal thinning was observed in the left eye, consistent with Terrien marginal degeneration. Chronic topical corticosteroid therapy was initiated with little, if any, subsequent disease progression. A perinuclear antineutrophil cytoplasmic antibody (p-ANCA)-positive vasculitis was subsequently diagnosed.

CONCLUSIONS

Fuchs superficial marginal keratitis and Terrien marginal degeneration may represent different clinical features of the same disease process. Laboratory investigation for underlying systemic disease may be warranted in patients with the appearance of either disorder. Chronic antiinflammatory therapy may be effective in limiting the progression of corneal thinning in these diseases.

Authors+Show Affiliations

F.I. Proctor Foundation, University of California, San Francisco, CA, USA. jeremy.keenan@ucsf.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21150425

Citation

Keenan, Jeremy D., et al. "Peripheral Ulcerative Keratitis Associated With Vasculitis Manifesting Asymmetrically as Fuchs Superficial Marginal Keratitis and Terrien Marginal Degeneration." Cornea, vol. 30, no. 7, 2011, pp. 825-7.
Keenan JD, Mandel MR, Margolis TP. Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration. Cornea. 2011;30(7):825-7.
Keenan, J. D., Mandel, M. R., & Margolis, T. P. (2011). Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration. Cornea, 30(7), 825-7. https://doi.org/10.1097/ICO.0b013e3182000c94
Keenan JD, Mandel MR, Margolis TP. Peripheral Ulcerative Keratitis Associated With Vasculitis Manifesting Asymmetrically as Fuchs Superficial Marginal Keratitis and Terrien Marginal Degeneration. Cornea. 2011;30(7):825-7. PubMed PMID: 21150425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration. AU - Keenan,Jeremy D, AU - Mandel,Mark R, AU - Margolis,Todd P, PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/9/29/medline SP - 825 EP - 7 JF - Cornea JO - Cornea VL - 30 IS - 7 N2 - PURPOSE: To report a case of bilateral peripheral corneal thinning with an appearance of Fuchs superficial marginal keratitis in the right eye and Terrien marginal degeneration in the left eye. METHODS: Interventional case report. RESULTS: A 28-year-old woman presented with bilateral corneal thinning and a pseudopterygium in the right eye and peripheral corneal thinning in the left eye. Laboratory examinations were negative. Over the next several years, the patient experienced periodic episodes of bilateral ocular redness and discomfort associated with gradual corneal thinning. However, other signs of progression were different in each eye. Pseudopterygium growth was observed in the right eye, consistent with Fuchs superficial marginal keratitis. Progressive lipid deposition at the leading edge of corneal thinning was observed in the left eye, consistent with Terrien marginal degeneration. Chronic topical corticosteroid therapy was initiated with little, if any, subsequent disease progression. A perinuclear antineutrophil cytoplasmic antibody (p-ANCA)-positive vasculitis was subsequently diagnosed. CONCLUSIONS: Fuchs superficial marginal keratitis and Terrien marginal degeneration may represent different clinical features of the same disease process. Laboratory investigation for underlying systemic disease may be warranted in patients with the appearance of either disorder. Chronic antiinflammatory therapy may be effective in limiting the progression of corneal thinning in these diseases. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/21150425/Peripheral_ulcerative_keratitis_associated_with_vasculitis_manifesting_asymmetrically_as_fuchs_superficial_marginal_keratitis_and_terrien_marginal_degeneration L2 - https://doi.org/10.1097/ICO.0b013e3182000c94 DB - PRIME DP - Unbound Medicine ER -