Tags

Type your tag names separated by a space and hit enter

Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist.
J Clin Endocrinol Metab. 1990 Jul; 71(1):92-7.JC

Abstract

As a preliminary step in searching for a pharmacological treatment for gonadotroph adenomas, we administered the GnRH antagonist analog Nal-Glu GnRH to five patients, four men and a woman, with FSH-secreting gonadotroph adenomas in order to determine its effect on FSH secretion. Administration of a single 10-mg dose of Nal-Glu GnRH to four of the patients produced a significant decrease in the serum FSH concentration in two patients and returned the FSH level to normal in only one. Administration of 5 mg Nal-Glu every 12 h for 7 days, however, produced a significant (P less than 0.001) decrease, and to within the normal range, in four of the five patients (mean +/- SEM, 32.7 +/- 5.6 IU/L during the 3 days before treatment and 9.8 +/- 1.4 IU/L during the last 3 days of treatment). Also, in response to the 7-day treatment, LH fell significantly in all five patients, alpha-subunit fell in three, and testosterone fell in all four men. Administration for 6 weeks of the GnRH agonist analog leuprolide did not decrease the serum FSH concentration of one of the patients whose serum FSH did decrease in response to Nal-Glu GnRH. We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion.

Authors+Show Affiliations

Daneshdoost L
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
Pavlou SN
No affiliation info available
Molitch ME
No affiliation info available
Gennarelli TA
No affiliation info available
Savino PJ
No affiliation info available
Sergott RC
No affiliation info available
Bosley TM
No affiliation info available
River JE
No affiliation info available
Vale WW
No affiliation info available
Snyder PJ
No affiliation info available

MeSH

AdenomaAdultAgedAmino Acid SequenceDose-Response Relationship, DrugFemaleFollicle Stimulating HormoneGonadotropin-Releasing HormoneHumansLeuprolideLuteinizing HormoneMaleMiddle AgedMolecular Sequence DataParaneoplastic Endocrine SyndromesPituitary NeoplasmsTestosteroneTime FactorsTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2115048

Citation

Daneshdoost, L, et al. "Inhibition of Follicle-stimulating Hormone Secretion From Gonadotroph Adenomas By Repetitive Administration of a Gonadotropin-releasing Hormone Antagonist." The Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 1, 1990, pp. 92-7.
Daneshdoost L, Pavlou SN, Molitch ME, et al. Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist. J Clin Endocrinol Metab. 1990;71(1):92-7.
Daneshdoost, L., Pavlou, S. N., Molitch, M. E., Gennarelli, T. A., Savino, P. J., Sergott, R. C., Bosley, T. M., River, J. E., Vale, W. W., & Snyder, P. J. (1990). Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist. The Journal of Clinical Endocrinology and Metabolism, 71(1), 92-7.
Daneshdoost L, et al. Inhibition of Follicle-stimulating Hormone Secretion From Gonadotroph Adenomas By Repetitive Administration of a Gonadotropin-releasing Hormone Antagonist. J Clin Endocrinol Metab. 1990;71(1):92-7. PubMed PMID: 2115048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist. AU - Daneshdoost,L, AU - Pavlou,S N, AU - Molitch,M E, AU - Gennarelli,T A, AU - Savino,P J, AU - Sergott,R C, AU - Bosley,T M, AU - River,J E, AU - Vale,W W, AU - Snyder,P J, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 92 EP - 7 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 71 IS - 1 N2 - As a preliminary step in searching for a pharmacological treatment for gonadotroph adenomas, we administered the GnRH antagonist analog Nal-Glu GnRH to five patients, four men and a woman, with FSH-secreting gonadotroph adenomas in order to determine its effect on FSH secretion. Administration of a single 10-mg dose of Nal-Glu GnRH to four of the patients produced a significant decrease in the serum FSH concentration in two patients and returned the FSH level to normal in only one. Administration of 5 mg Nal-Glu every 12 h for 7 days, however, produced a significant (P less than 0.001) decrease, and to within the normal range, in four of the five patients (mean +/- SEM, 32.7 +/- 5.6 IU/L during the 3 days before treatment and 9.8 +/- 1.4 IU/L during the last 3 days of treatment). Also, in response to the 7-day treatment, LH fell significantly in all five patients, alpha-subunit fell in three, and testosterone fell in all four men. Administration for 6 weeks of the GnRH agonist analog leuprolide did not decrease the serum FSH concentration of one of the patients whose serum FSH did decrease in response to Nal-Glu GnRH. We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2115048/Inhibition_of_follicle_stimulating_hormone_secretion_from_gonadotroph_adenomas_by_repetitive_administration_of_a_gonadotropin_releasing_hormone_antagonist_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓2]

Related Citations

More