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α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease.
Int J Mol Sci. 2010 Oct 29; 11(11):4257-66.IJ

Abstract

Parkinson's disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, α-synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may be altered during the progression of PD. In this regard, sensitive and accurate methods for evaluation of α-synuclein and DJ-1 levels in the CSF and blood have been developed, and the results suggest that the levels of both molecules are significantly decreased in the CSF in patients with PD compared with age-matched controls. Furthermore, specific detection and quantification of neurotoxic oligometric forms of α-synuclein in the blood using enzyme-linked immunosorbent assays might be expected as potential peripheral biomarkers for PD, although further validation is required. Currently, neither α-synuclein nor DJ-1 is satisfactory as a single biomarker for PD, but combinatory evaluation of these biological fluid molecules with other biomarkers and imaging techniques may provide reliable information for diagnosis of PD.

Authors+Show Affiliations

Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo, 183-8526, Japan; E-Mails: sekiyama-kz@igakuken.or.jp (K.S.); sekigawa-ak@igakuken.or.jp (A.S.); takamatsu-ys@igakuken.or.jp (Y.T.); fujita-ms@igakuken.or.jp (M.F.); hashimoto-mk@igakuken.or.jp (M.H.).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21151436

Citation

Waragai, Masaaki, et al. "Α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson's Disease." International Journal of Molecular Sciences, vol. 11, no. 11, 2010, pp. 4257-66.
Waragai M, Sekiyama K, Sekigawa A, et al. Α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease. Int J Mol Sci. 2010;11(11):4257-66.
Waragai, M., Sekiyama, K., Sekigawa, A., Takamatsu, Y., Fujita, M., & Hashimoto, M. (2010). Α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease. International Journal of Molecular Sciences, 11(11), 4257-66. https://doi.org/10.3390/ijms11114257
Waragai M, et al. Α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson's Disease. Int J Mol Sci. 2010 Oct 29;11(11):4257-66. PubMed PMID: 21151436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease. AU - Waragai,Masaaki, AU - Sekiyama,Kazunari, AU - Sekigawa,Akio, AU - Takamatsu,Yoshiki, AU - Fujita,Masayo, AU - Hashimoto,Makoto, Y1 - 2010/10/29/ PY - 2010/09/14/received PY - 2010/10/20/revised PY - 2010/10/28/accepted PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2010/12/15/medline KW - DJ-1 KW - Parkinson’s disease KW - biomarker KW - cerebrospinal fluid KW - α-synuclein SP - 4257 EP - 66 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 11 IS - 11 N2 - Parkinson's disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, α-synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may be altered during the progression of PD. In this regard, sensitive and accurate methods for evaluation of α-synuclein and DJ-1 levels in the CSF and blood have been developed, and the results suggest that the levels of both molecules are significantly decreased in the CSF in patients with PD compared with age-matched controls. Furthermore, specific detection and quantification of neurotoxic oligometric forms of α-synuclein in the blood using enzyme-linked immunosorbent assays might be expected as potential peripheral biomarkers for PD, although further validation is required. Currently, neither α-synuclein nor DJ-1 is satisfactory as a single biomarker for PD, but combinatory evaluation of these biological fluid molecules with other biomarkers and imaging techniques may provide reliable information for diagnosis of PD. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/21151436/α_Synuclein_and_DJ_1_as_potential_biological_fluid_biomarkers_for_Parkinson's_Disease_ L2 - https://doi.org/10.3390/ijms11114257 DB - PRIME DP - Unbound Medicine ER -