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Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice.
Planta Med. 2011 May; 77(8):786-94.PM

Abstract

Mulberroside A is a major stilbene glycoside of MORUS ALBA L. (Moraceae), which is effectively used for the treatment of hyperuricemia and gout in traditional Chinese medicine. We examined whether mulberroside A had effects on renal urate underexcretion and dysfunction in oxonate-induced hyperuricemic mice and investigated the potential uricosuric and nephroprotective mechanisms involved. Mulberroside A at 10, 20, and 40 mg/kg decreased serum uric acid levels and increased urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice. Simultaneously, it reduced serum levels of creatinine and urea nitrogen (10-40 mg/kg), urinary N-acetyl- β-D-glucosaminidase activity (10-40 mg/kg), β₂-microglobulin (10-40 mg/kg) and albumin (20-40 mg/kg), and increased creatinine clearance (10-40 mg/kg) in hyperuricemic mice. Furthermore, mulberroside A downregulated mRNA and protein levels of renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1), and upregulated mRNA and protein levels of renal organic anion transporter 1 (mOAT1) and organic cation and carnitine transporters (mOCT1, mOCT2, mOCTN1, and mOCTN2) in hyperuricemic mice. This is the first study demonstrating that mulberroside A exhibits uricosuric and nephroprotective effects mediated in part by cooperative attenuation of the expression alterations of renal organic ion transporters in hyperuricemic mice. These data suggest that mulberroside A may be a new drug candidate for the treatment of hyperuricemia with renal dysfunction.

Authors+Show Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21154198

Citation

Wang, Cai-Ping, et al. "Mulberroside a Possesses Potent Uricosuric and Nephroprotective Effects in Hyperuricemic Mice." Planta Medica, vol. 77, no. 8, 2011, pp. 786-94.
Wang CP, Wang Y, Wang X, et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 2011;77(8):786-94.
Wang, C. P., Wang, Y., Wang, X., Zhang, X., Ye, J. F., Hu, L. S., & Kong, L. D. (2011). Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Medica, 77(8), 786-94. https://doi.org/10.1055/s-0030-1250599
Wang CP, et al. Mulberroside a Possesses Potent Uricosuric and Nephroprotective Effects in Hyperuricemic Mice. Planta Med. 2011;77(8):786-94. PubMed PMID: 21154198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. AU - Wang,Cai-Ping, AU - Wang,Yemin, AU - Wang,Xing, AU - Zhang,Xian, AU - Ye,Jian-Feng, AU - Hu,Lin-Shui, AU - Kong,Ling-Dong, Y1 - 2010/12/10/ PY - 2010/12/15/entrez PY - 2010/12/15/pubmed PY - 2011/8/19/medline SP - 786 EP - 94 JF - Planta medica JO - Planta Med. VL - 77 IS - 8 N2 - Mulberroside A is a major stilbene glycoside of MORUS ALBA L. (Moraceae), which is effectively used for the treatment of hyperuricemia and gout in traditional Chinese medicine. We examined whether mulberroside A had effects on renal urate underexcretion and dysfunction in oxonate-induced hyperuricemic mice and investigated the potential uricosuric and nephroprotective mechanisms involved. Mulberroside A at 10, 20, and 40 mg/kg decreased serum uric acid levels and increased urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice. Simultaneously, it reduced serum levels of creatinine and urea nitrogen (10-40 mg/kg), urinary N-acetyl- β-D-glucosaminidase activity (10-40 mg/kg), β₂-microglobulin (10-40 mg/kg) and albumin (20-40 mg/kg), and increased creatinine clearance (10-40 mg/kg) in hyperuricemic mice. Furthermore, mulberroside A downregulated mRNA and protein levels of renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1), and upregulated mRNA and protein levels of renal organic anion transporter 1 (mOAT1) and organic cation and carnitine transporters (mOCT1, mOCT2, mOCTN1, and mOCTN2) in hyperuricemic mice. This is the first study demonstrating that mulberroside A exhibits uricosuric and nephroprotective effects mediated in part by cooperative attenuation of the expression alterations of renal organic ion transporters in hyperuricemic mice. These data suggest that mulberroside A may be a new drug candidate for the treatment of hyperuricemia with renal dysfunction. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/21154198/Mulberroside_a_possesses_potent_uricosuric_and_nephroprotective_effects_in_hyperuricemic_mice_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1250599 DB - PRIME DP - Unbound Medicine ER -