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Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report.
J Obstet Gynaecol Res. 2011 Jun; 37(6):661-3.JO

Abstract

Impetigo herpetiformis is a rare disease and its occurrence is specific for pregnancy. The lesions are characterized by sterile, pustular eruptions. The disorder is usually seen in the third trimester, but cases of impetigo herpetiformis appearing in the first trimester have also been reported. The lesions are expected to disappear after birth, but the disorder may recur during subsequent pregnancies. In this case report we discuss a 28-year-old pregnant woman, G3P1011, with a history of impetigo herpetiformis in the first pregnancy, who presented with generalized pustular lesions at 30 weeks' gestation. Her disease responded poorly to corticosteroids and was more severe than in the previous pregnancy. She delivered prematurely at 34 weeks' gestation and then received aggressive postpartum treatment with methotrexate, resulting in a dramatic response. This case supports the current understanding that recurrent impetigo herpetiformis in subsequent pregnancy tends to be more severe and to have an earlier onset. Additionally, it provides additional evidence that methotrexate may be used as an alternative treatment for impetigo herpetiformis in the case of a poor response to corticosteroids.

Authors+Show Affiliations

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Chiang Mai University, Chiang Mai, Thailand.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21159049

Citation

Luewan, Suchaya, et al. "Recurrent Impetigo Herpetiformis Successfully Treated With Methotrexate: a Case Report." The Journal of Obstetrics and Gynaecology Research, vol. 37, no. 6, 2011, pp. 661-3.
Luewan S, Sirichotiyakul S, Tongsong T. Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. J Obstet Gynaecol Res. 2011;37(6):661-3.
Luewan, S., Sirichotiyakul, S., & Tongsong, T. (2011). Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. The Journal of Obstetrics and Gynaecology Research, 37(6), 661-3. https://doi.org/10.1111/j.1447-0756.2010.01418.x
Luewan S, Sirichotiyakul S, Tongsong T. Recurrent Impetigo Herpetiformis Successfully Treated With Methotrexate: a Case Report. J Obstet Gynaecol Res. 2011;37(6):661-3. PubMed PMID: 21159049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report. AU - Luewan,Suchaya, AU - Sirichotiyakul,Supatra, AU - Tongsong,Theera, Y1 - 2010/12/15/ PY - 2010/12/17/entrez PY - 2010/12/17/pubmed PY - 2012/1/24/medline SP - 661 EP - 3 JF - The journal of obstetrics and gynaecology research JO - J Obstet Gynaecol Res VL - 37 IS - 6 N2 - Impetigo herpetiformis is a rare disease and its occurrence is specific for pregnancy. The lesions are characterized by sterile, pustular eruptions. The disorder is usually seen in the third trimester, but cases of impetigo herpetiformis appearing in the first trimester have also been reported. The lesions are expected to disappear after birth, but the disorder may recur during subsequent pregnancies. In this case report we discuss a 28-year-old pregnant woman, G3P1011, with a history of impetigo herpetiformis in the first pregnancy, who presented with generalized pustular lesions at 30 weeks' gestation. Her disease responded poorly to corticosteroids and was more severe than in the previous pregnancy. She delivered prematurely at 34 weeks' gestation and then received aggressive postpartum treatment with methotrexate, resulting in a dramatic response. This case supports the current understanding that recurrent impetigo herpetiformis in subsequent pregnancy tends to be more severe and to have an earlier onset. Additionally, it provides additional evidence that methotrexate may be used as an alternative treatment for impetigo herpetiformis in the case of a poor response to corticosteroids. SN - 1447-0756 UR - https://www.unboundmedicine.com/medline/citation/21159049/Recurrent_impetigo_herpetiformis_successfully_treated_with_methotrexate:_a_case_report_ L2 - https://doi.org/10.1111/j.1447-0756.2010.01418.x DB - PRIME DP - Unbound Medicine ER -