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A parallel open-label trial to evaluate microbial cellulose wound dressing in the treatment of diabetic foot ulcers.

Abstract

The purpose of this study was to compare the rate of wound healing in diabetic foot ulcers (DFU) using either a microbial cellulose (MC) wound dressing or Xeroform™ Petrolatum gauze. In a parallel, open-label trial in which the primary outcome was the rate of wound healing and the time to wound closure, 15 ulcers in type II diabetic patients received an MC dressing. Wounds in 19 control patients with type II diabetes were treated with a Xeroform gauze dressing. All wounds were non infected, Wagner stage II or III and received standard care including debridement, non weight bearing limb support and weekly wound evaluation. The mean time to heal in the MC (±SE) treated group was 32 days ± 2.5 and for controls it was 48 days ± 4.7 (P < 0.01). The rate of weekly wound closure (mean ± SE) was 1.7 times faster in the MC-treated group (cellulose treated, -5.04% per week ± 0.38 versus control, -2.93% per week ± 0.19), (P < 0.001). Among covariants tested by univariate regression, only the original wound area correlated with the time to wound closure (P < 0.001). In conclusion, with the provision of current standards of care, the application of an MC dressing to a diabetic ulcer may enhance the rate of wound healing and shorten the time course of epithelisation.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Illinois Bone and Joint Institute, Chicago, IL, USA.

    ,

    Source

    International wound journal 8:1 2011 Feb pg 69-73

    MeSH

    Aged
    Bandages
    Cellulose
    Diabetic Foot
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Petrolatum
    Treatment Outcome
    Wound Healing

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    21159127

    Citation

    Solway, Douglas R., et al. "A Parallel Open-label Trial to Evaluate Microbial Cellulose Wound Dressing in the Treatment of Diabetic Foot Ulcers." International Wound Journal, vol. 8, no. 1, 2011, pp. 69-73.
    Solway DR, Clark WA, Levinson DJ. A parallel open-label trial to evaluate microbial cellulose wound dressing in the treatment of diabetic foot ulcers. Int Wound J. 2011;8(1):69-73.
    Solway, D. R., Clark, W. A., & Levinson, D. J. (2011). A parallel open-label trial to evaluate microbial cellulose wound dressing in the treatment of diabetic foot ulcers. International Wound Journal, 8(1), pp. 69-73. doi:10.1111/j.1742-481X.2010.00750.x.
    Solway DR, Clark WA, Levinson DJ. A Parallel Open-label Trial to Evaluate Microbial Cellulose Wound Dressing in the Treatment of Diabetic Foot Ulcers. Int Wound J. 2011;8(1):69-73. PubMed PMID: 21159127.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A parallel open-label trial to evaluate microbial cellulose wound dressing in the treatment of diabetic foot ulcers. AU - Solway,Douglas R, AU - Clark,William A, AU - Levinson,Dennis J, Y1 - 2010/12/16/ PY - 2010/12/17/entrez PY - 2010/12/17/pubmed PY - 2011/6/15/medline SP - 69 EP - 73 JF - International wound journal JO - Int Wound J VL - 8 IS - 1 N2 - The purpose of this study was to compare the rate of wound healing in diabetic foot ulcers (DFU) using either a microbial cellulose (MC) wound dressing or Xeroform™ Petrolatum gauze. In a parallel, open-label trial in which the primary outcome was the rate of wound healing and the time to wound closure, 15 ulcers in type II diabetic patients received an MC dressing. Wounds in 19 control patients with type II diabetes were treated with a Xeroform gauze dressing. All wounds were non infected, Wagner stage II or III and received standard care including debridement, non weight bearing limb support and weekly wound evaluation. The mean time to heal in the MC (±SE) treated group was 32 days ± 2.5 and for controls it was 48 days ± 4.7 (P < 0.01). The rate of weekly wound closure (mean ± SE) was 1.7 times faster in the MC-treated group (cellulose treated, -5.04% per week ± 0.38 versus control, -2.93% per week ± 0.19), (P < 0.001). Among covariants tested by univariate regression, only the original wound area correlated with the time to wound closure (P < 0.001). In conclusion, with the provision of current standards of care, the application of an MC dressing to a diabetic ulcer may enhance the rate of wound healing and shorten the time course of epithelisation. SN - 1742-481X UR - https://www.unboundmedicine.com/medline/citation/21159127/A_parallel_open_label_trial_to_evaluate_microbial_cellulose_wound_dressing_in_the_treatment_of_diabetic_foot_ulcers_ L2 - https://doi.org/10.1111/j.1742-481X.2010.00750.x DB - PRIME DP - Unbound Medicine ER -