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Desmopressin is an effective treatment for mixed nocturia with nocturnal polyuria and decreased nocturnal bladder capacity.
J Korean Med Sci. 2010 Dec; 25(12):1792-7.JK

Abstract

To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged ≥ 18 yr with mixed nocturia (≥ 2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was the proportion of patients with a 50% or greater reduction in the number of nocturnal voids (NV) compared with baseline. Among 103 patients enrolled, 94 (79 men and 15 women) were included in the analysis. The proportion of patients with a 50% or greater reduction in NV was 68 (72%). The mean number of NV decreased significantly (3.20 to 1.34) and the mean nocturnal urine volume, nocturia index, NPi, and NBCi decreased significantly. The mean duration of sleep until the first NV was prolonged from 118.4 ± 44.1 to 220.3 ± 90.7 min (P<0.001). The overall impression of patients about their quality of sleep improved. Adverse events occurred in 6 patients, including one asymptomatic hyponatremia. Desmopressin is an effective and well-tolerated treatment for mixed nocturia.

Links

Publisher Full Text
ncbi.nlm.nih.gov
jkms.org
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Authors+Show Affiliations

Lee HW
Department of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Korea.
Choo MS
No affiliation info available
Lee JG
No affiliation info available
Park CH
No affiliation info available
Paick JS
No affiliation info available
Lee JZ
No affiliation info available
Han DH
No affiliation info available
Park WH
No affiliation info available
Lee KS
No affiliation info available

MeSH

Administration, OralAdultAgedAged, 80 and overAntidiuretic AgentsDeamino Arginine VasopressinDrug Administration ScheduleFemaleHumansMaleMiddle AgedNocturiaPolyuriaProspective StudiesSleepSurveys and QuestionnairesUrinary BladderUrodynamics

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

21165296

Citation

Lee, Hye Won, et al. "Desmopressin Is an Effective Treatment for Mixed Nocturia With Nocturnal Polyuria and Decreased Nocturnal Bladder Capacity." Journal of Korean Medical Science, vol. 25, no. 12, 2010, pp. 1792-7.
Lee HW, Choo MS, Lee JG, et al. Desmopressin is an effective treatment for mixed nocturia with nocturnal polyuria and decreased nocturnal bladder capacity. J Korean Med Sci. 2010;25(12):1792-7.
Lee, H. W., Choo, M. S., Lee, J. G., Park, C. H., Paick, J. S., Lee, J. Z., Han, D. H., Park, W. H., & Lee, K. S. (2010). Desmopressin is an effective treatment for mixed nocturia with nocturnal polyuria and decreased nocturnal bladder capacity. Journal of Korean Medical Science, 25(12), 1792-7. https://doi.org/10.3346/jkms.2010.25.12.1792
Lee HW, et al. Desmopressin Is an Effective Treatment for Mixed Nocturia With Nocturnal Polyuria and Decreased Nocturnal Bladder Capacity. J Korean Med Sci. 2010;25(12):1792-7. PubMed PMID: 21165296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Desmopressin is an effective treatment for mixed nocturia with nocturnal polyuria and decreased nocturnal bladder capacity. AU - Lee,Hye Won, AU - Choo,Myung-Soo, AU - Lee,Jeong Gu, AU - Park,Choal Hee, AU - Paick,Jae-Seung, AU - Lee,Jeong Zoo, AU - Han,Deok Hyun, AU - Park,Won Hee, AU - Lee,Kyu-Sung, Y1 - 2010/11/24/ PY - 2010/04/21/received PY - 2010/07/22/accepted PY - 2010/12/18/entrez PY - 2010/12/18/pubmed PY - 2011/4/8/medline KW - Deamino Arginine Vasopressin KW - Hyponatremia KW - Nocturia KW - Nocturnal Polyuria KW - Urinary Bladder SP - 1792 EP - 7 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 25 IS - 12 N2 - To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged ≥ 18 yr with mixed nocturia (≥ 2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was the proportion of patients with a 50% or greater reduction in the number of nocturnal voids (NV) compared with baseline. Among 103 patients enrolled, 94 (79 men and 15 women) were included in the analysis. The proportion of patients with a 50% or greater reduction in NV was 68 (72%). The mean number of NV decreased significantly (3.20 to 1.34) and the mean nocturnal urine volume, nocturia index, NPi, and NBCi decreased significantly. The mean duration of sleep until the first NV was prolonged from 118.4 ± 44.1 to 220.3 ± 90.7 min (P<0.001). The overall impression of patients about their quality of sleep improved. Adverse events occurred in 6 patients, including one asymptomatic hyponatremia. Desmopressin is an effective and well-tolerated treatment for mixed nocturia. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/21165296/Desmopressin_is_an_effective_treatment_for_mixed_nocturia_with_nocturnal_polyuria_and_decreased_nocturnal_bladder_capacity_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2010.25.12.1792 DB - PRIME DP - Unbound Medicine ER -
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