Tags

Type your tag names separated by a space and hit enter

[Effects of genistein on bone mineralization in ovariectomized rats].

Abstract

AIM

To investigate the effects of genistein on bone mineralization in ovariectomized rats.

METHODS

Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovariectomized (ovx), ovariectomized supplied with diethyl stilbestrol (E, 20 microg x kg bw(-1) x d(-1)) or genistein (25, 50, 100 mg x kg bw(-1) x d(-1)). After the rats had been fed for three months, analysis of the bone mineral density, parameters related to mineralization, bone content of Ca, P, Mg, Mn and Zn and serum concentration of parathyroid calcitonin and estrogen was performed.

RESULTS

Bone mineral density, bone Ca, P, Zn and Mg content and serum estrogen concentration in ovariectomized rats were significantly decreased, but mean osteoid width increased, mineralization lag time and osteoid maturation period prolonged compared with sham animals. After three months supplementation to ovariectomized rats, bone Ca, P and Mg content increased, mean osteoid width decreased, mineralization lag time and osteoid maturation period shortened compared with ovariectomized animals.

CONCLUSION

Genistein promotes bone mineralization by increasing bone Ca, P, Mg and adjusting serum calcitonin to prevent osteoporosis.

Authors+Show Affiliations

Department of Nutrition, General Hospital of Chinese PLA, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

21166175

Citation

Zhang, Yue-hong, et al. "[Effects of Genistein On Bone Mineralization in Ovariectomized Rats]." Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, vol. 21, no. 1, 2005, pp. 86-9.
Zhang YH, Jin H, Xu ZQ, et al. [Effects of genistein on bone mineralization in ovariectomized rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21(1):86-9.
Zhang, Y. H., Jin, H., Xu, Z. Q., Nan, W. K., Wang, X. Y., Xue, C. Y., & Gao, L. X. (2005). [Effects of genistein on bone mineralization in ovariectomized rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, 21(1), 86-9.
Zhang YH, et al. [Effects of Genistein On Bone Mineralization in Ovariectomized Rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21(1):86-9. PubMed PMID: 21166175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of genistein on bone mineralization in ovariectomized rats]. AU - Zhang,Yue-hong, AU - Jin,Hong, AU - Xu,Zhi-qin, AU - Nan,Wen-kao, AU - Wang,Xian-yuan, AU - Xue,Chang-yong, AU - Gao,Lan-xing, PY - 2010/12/21/entrez PY - 2005/2/1/pubmed PY - 2012/8/25/medline SP - 86 EP - 9 JF - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology JO - Zhongguo Ying Yong Sheng Li Xue Za Zhi VL - 21 IS - 1 N2 - AIM: To investigate the effects of genistein on bone mineralization in ovariectomized rats. METHODS: Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovariectomized (ovx), ovariectomized supplied with diethyl stilbestrol (E, 20 microg x kg bw(-1) x d(-1)) or genistein (25, 50, 100 mg x kg bw(-1) x d(-1)). After the rats had been fed for three months, analysis of the bone mineral density, parameters related to mineralization, bone content of Ca, P, Mg, Mn and Zn and serum concentration of parathyroid calcitonin and estrogen was performed. RESULTS: Bone mineral density, bone Ca, P, Zn and Mg content and serum estrogen concentration in ovariectomized rats were significantly decreased, but mean osteoid width increased, mineralization lag time and osteoid maturation period prolonged compared with sham animals. After three months supplementation to ovariectomized rats, bone Ca, P and Mg content increased, mean osteoid width decreased, mineralization lag time and osteoid maturation period shortened compared with ovariectomized animals. CONCLUSION: Genistein promotes bone mineralization by increasing bone Ca, P, Mg and adjusting serum calcitonin to prevent osteoporosis. SN - 1000-6834 UR - https://www.unboundmedicine.com/medline/citation/21166175/[Effects_of_genistein_on_bone_mineralization_in_ovariectomized_rats]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -