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Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma.
Histopathology. 2010 Dec; 57(6):796-805.H

Abstract

AIMS

To determine the contributions of mast cells (MC), eosinophil leucocytes (EL) and microvessel density (MVD) in lip carcinogenesis, and to establish the relationships between these biomarkers and their possible prognostic value in lip squamous cell carcinoma (LSCC).

METHODS AND RESULTS

Archived specimens of lip mucosa (n=13), actinic cheilitis (n=29) and LSCC (n=29) were formalin-fixed, paraffin-embedded, sectioned and stained with toluidine blue and haematoxylin and eosin (H&E) in order to identify MC and EL and to measure their densities. Tumour angiogenesis was estimated by determining, with the use of CD31 antibody MVD in areas with the highest number of stained microvessels ('hot spots'). Progressive increases of MC, EL and MVD were observed during lip tumour development. Correlation analysis revealed positive associations between the biomarkers during tumour progression. In LSCC samples, significant associations were found between MVD values and metastatic disease. On multivariate analysis, MVD was a predictor of risk of cervical metastasis.

CONCLUSIONS

The densities of MC, EL and microvessels increase during lip carcinogenesis, and for MC and EL this may be related to the stimulation of tumour angiogenesis. MVD could be a useful predictor of cervical metastasis in LSCC.

Authors+Show Affiliations

Health Science Programme, State University of Montes Claros, Montes Claros, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21166694

Citation

Souza, Ludmilla R., et al. "Association of Mast Cell, Eosinophil Leucocyte and Microvessel Densities in Actinic Cheilitis and Lip Squamous Cell Carcinoma." Histopathology, vol. 57, no. 6, 2010, pp. 796-805.
Souza LR, Fonseca-Silva T, Santos CC, et al. Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma. Histopathology. 2010;57(6):796-805.
Souza, L. R., Fonseca-Silva, T., Santos, C. C., Oliveira, M. V., Corrêa-Oliveira, R., Guimarães, A. L., & De Paula, A. M. (2010). Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma. Histopathology, 57(6), 796-805. https://doi.org/10.1111/j.1365-2559.2010.03721.x
Souza LR, et al. Association of Mast Cell, Eosinophil Leucocyte and Microvessel Densities in Actinic Cheilitis and Lip Squamous Cell Carcinoma. Histopathology. 2010;57(6):796-805. PubMed PMID: 21166694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma. AU - Souza,Ludmilla R, AU - Fonseca-Silva,Thiago, AU - Santos,Carolina C O, AU - Oliveira,Marcos V M, AU - Corrêa-Oliveira,Rodrigo, AU - Guimarães,André L S, AU - De Paula,Alfredo M B, PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/4/9/medline SP - 796 EP - 805 JF - Histopathology JO - Histopathology VL - 57 IS - 6 N2 - AIMS: To determine the contributions of mast cells (MC), eosinophil leucocytes (EL) and microvessel density (MVD) in lip carcinogenesis, and to establish the relationships between these biomarkers and their possible prognostic value in lip squamous cell carcinoma (LSCC). METHODS AND RESULTS: Archived specimens of lip mucosa (n=13), actinic cheilitis (n=29) and LSCC (n=29) were formalin-fixed, paraffin-embedded, sectioned and stained with toluidine blue and haematoxylin and eosin (H&E) in order to identify MC and EL and to measure their densities. Tumour angiogenesis was estimated by determining, with the use of CD31 antibody MVD in areas with the highest number of stained microvessels ('hot spots'). Progressive increases of MC, EL and MVD were observed during lip tumour development. Correlation analysis revealed positive associations between the biomarkers during tumour progression. In LSCC samples, significant associations were found between MVD values and metastatic disease. On multivariate analysis, MVD was a predictor of risk of cervical metastasis. CONCLUSIONS: The densities of MC, EL and microvessels increase during lip carcinogenesis, and for MC and EL this may be related to the stimulation of tumour angiogenesis. MVD could be a useful predictor of cervical metastasis in LSCC. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/21166694/Association_of_mast_cell_eosinophil_leucocyte_and_microvessel_densities_in_actinic_cheilitis_and_lip_squamous_cell_carcinoma_ L2 - https://doi.org/10.1111/j.1365-2559.2010.03721.x DB - PRIME DP - Unbound Medicine ER -