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α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice.
Exp Dermatol. 2011 Feb; 20(2):97-101.ED

Abstract

Atopic dermatitis (AD) is a common skin disease that has complex pathogenic mechanisms. Under specific pathogen-free conditions, repeated epicutaneous treatment of 2-4-dinitrofluorobenzene (DNFB) evokes AD-like clinical symptoms in NC/Nga mice. α-Lipoic acid (α-LA; 1, 2-dithiolane-3-pentanoic acid) is a dietary component that is synthesized in bacteria, yeast, plants, and mammals. α-LA and its reduced form, dihydrolipoic acid, are powerful antioxidants that have many physiological functions, including free radical scavenging of reactive oxygen species, generation of cellular antioxidants, chelation of metal ions, and inflammatory suppression. In this study, we investigated whether α-LA suppresses AD-like skin lesions induced by repeated DNFB application in NC/Nga mice. α-LA significantly suppressed production of interferon (IFN)-γ and interleukin (IL)-4 by activated CD4(+) T cells. We found that the oral administration of α-LA reduced AD-like clinical symptoms and inhibited increases of epidermal thickness in DNFB-induced AD-like skin lesions of NC/Nga mice. Furthermore, total serum IgE levels were dramatically reduced by topical α-LA treatment. Our findings suggest that oral administration of α-LA suppresses the development of AD in DNFB-treated NC/Nga mice and reduces IFN-γ and IL-4 production from activated CD4(+) T cells as well as total serum IgE levels.

Authors+Show Affiliations

Department of Microbiology (BK21), College of Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21166725

Citation

Kim, Gun-Dong, et al. "Α-Lipoic Acid Suppresses the Development of DNFB-induced Atopic Dermatitis-like Symptoms in NC/Nga Mice." Experimental Dermatology, vol. 20, no. 2, 2011, pp. 97-101.
Kim GD, Kim TH, Jang AH, et al. Α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice. Exp Dermatol. 2011;20(2):97-101.
Kim, G. D., Kim, T. H., Jang, A. H., Ahn, H. J., Park, Y. S., & Park, C. S. (2011). Α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice. Experimental Dermatology, 20(2), 97-101. https://doi.org/10.1111/j.1600-0625.2010.01165.x
Kim GD, et al. Α-Lipoic Acid Suppresses the Development of DNFB-induced Atopic Dermatitis-like Symptoms in NC/Nga Mice. Exp Dermatol. 2011;20(2):97-101. PubMed PMID: 21166725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice. AU - Kim,Gun-Dong, AU - Kim,Tae-Ho, AU - Jang,An-Hee, AU - Ahn,Hyun-Jong, AU - Park,Yong Seek, AU - Park,Cheung-Seog, Y1 - 2010/12/17/ PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/6/22/medline SP - 97 EP - 101 JF - Experimental dermatology JO - Exp Dermatol VL - 20 IS - 2 N2 - Atopic dermatitis (AD) is a common skin disease that has complex pathogenic mechanisms. Under specific pathogen-free conditions, repeated epicutaneous treatment of 2-4-dinitrofluorobenzene (DNFB) evokes AD-like clinical symptoms in NC/Nga mice. α-Lipoic acid (α-LA; 1, 2-dithiolane-3-pentanoic acid) is a dietary component that is synthesized in bacteria, yeast, plants, and mammals. α-LA and its reduced form, dihydrolipoic acid, are powerful antioxidants that have many physiological functions, including free radical scavenging of reactive oxygen species, generation of cellular antioxidants, chelation of metal ions, and inflammatory suppression. In this study, we investigated whether α-LA suppresses AD-like skin lesions induced by repeated DNFB application in NC/Nga mice. α-LA significantly suppressed production of interferon (IFN)-γ and interleukin (IL)-4 by activated CD4(+) T cells. We found that the oral administration of α-LA reduced AD-like clinical symptoms and inhibited increases of epidermal thickness in DNFB-induced AD-like skin lesions of NC/Nga mice. Furthermore, total serum IgE levels were dramatically reduced by topical α-LA treatment. Our findings suggest that oral administration of α-LA suppresses the development of AD in DNFB-treated NC/Nga mice and reduces IFN-γ and IL-4 production from activated CD4(+) T cells as well as total serum IgE levels. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/21166725/α_Lipoic_acid_suppresses_the_development_of_DNFB_induced_atopic_dermatitis_like_symptoms_in_NC/Nga_mice_ L2 - https://doi.org/10.1111/j.1600-0625.2010.01165.x DB - PRIME DP - Unbound Medicine ER -