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A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort.
Atherosclerosis 2011; 214(2):391-6A

Abstract

OBJECTIVE

Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population.

METHODS

1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography.

RESULTS

In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P=0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥ 1 mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein.

CONCLUSION

This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21167485

Citation

Deng, Han-Bing, et al. "A Polymorphism in Transforming Growth Factor-β1 Is Associated With Carotid Plaques and Increased Carotid Intima-media Thickness in Older Chinese Men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort." Atherosclerosis, vol. 214, no. 2, 2011, pp. 391-6.
Deng HB, Jiang CQ, Tomlinson B, et al. A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Atherosclerosis. 2011;214(2):391-6.
Deng, H. B., Jiang, C. Q., Tomlinson, B., Liu, B., Lin, J. M., Wong, K. S., ... Thomas, G. N. (2011). A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Atherosclerosis, 214(2), pp. 391-6. doi:10.1016/j.atherosclerosis.2010.11.025.
Deng HB, et al. A Polymorphism in Transforming Growth Factor-β1 Is Associated With Carotid Plaques and Increased Carotid Intima-media Thickness in Older Chinese Men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Atherosclerosis. 2011;214(2):391-6. PubMed PMID: 21167485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. AU - Deng,Han-Bing, AU - Jiang,Chao Qiang, AU - Tomlinson,Brian, AU - Liu,Bin, AU - Lin,Jie Ming, AU - Wong,Ka Sing, AU - Cheung,Bernard M Y, AU - Lam,Tai Hing, AU - Thomas,G Neil, Y1 - 2010/11/26/ PY - 2010/08/13/received PY - 2010/11/15/revised PY - 2010/11/15/accepted PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/5/24/medline SP - 391 EP - 6 JF - Atherosclerosis JO - Atherosclerosis VL - 214 IS - 2 N2 - OBJECTIVE: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. METHODS: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. RESULTS: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P=0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥ 1 mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. CONCLUSION: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/21167485/A_polymorphism_in_transforming_growth_factor_β1_is_associated_with_carotid_plaques_and_increased_carotid_intima_media_thickness_in_older_Chinese_men:_the_Guangzhou_Biobank_Cohort_Study_Cardiovascular_Disease_Subcohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(10)00964-0 DB - PRIME DP - Unbound Medicine ER -