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Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity.

Abstract

Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease. The present paper summarizes research showing that Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus. The paper then considers evidence that saturated fat and simple carbohydrate intake is correlated with neurobiological changes in the hippocampus that may be related to the ability of these dietary components to impair cognitive function. Finally, a model is described proposing that Western diet consumption contributes to the development of excessive food intake and obesity, in part, by interfering with a type of hippocampal-dependent memory inhibition that is critical in the ability of animals to refrain from responding to environmental cues associated with food, and ultimately from consuming energy intake in excess of that driven solely by caloric need.

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  • Authors+Show Affiliations

    ,

    University of Pennsylvania, Department of Psychology, Philadelphia, PA, United States. davidson@psych.purdue.edu

    Source

    Physiology & behavior 103:1 2011 Apr 18 pg 59-68

    MeSH

    Animals
    Blood-Brain Barrier
    Cognition Disorders
    Dietary Carbohydrates
    Dietary Fats
    Energy Intake
    Hippocampus
    Humans
    Learning Disorders
    Memory Disorders
    Obesity

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21167850

    Citation

    Kanoski, Scott E., and Terry L. Davidson. "Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity." Physiology & Behavior, vol. 103, no. 1, 2011, pp. 59-68.
    Kanoski SE, Davidson TL. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav. 2011;103(1):59-68.
    Kanoski, S. E., & Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & Behavior, 103(1), pp. 59-68. doi:10.1016/j.physbeh.2010.12.003.
    Kanoski SE, Davidson TL. Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity. Physiol Behav. 2011 Apr 18;103(1):59-68. PubMed PMID: 21167850.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. AU - Kanoski,Scott E, AU - Davidson,Terry L, Y1 - 2010/12/16/ PY - 2010/09/24/received PY - 2010/11/05/revised PY - 2010/12/04/accepted PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/7/2/medline SP - 59 EP - 68 JF - Physiology & behavior JO - Physiol. Behav. VL - 103 IS - 1 N2 - Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease. The present paper summarizes research showing that Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus. The paper then considers evidence that saturated fat and simple carbohydrate intake is correlated with neurobiological changes in the hippocampus that may be related to the ability of these dietary components to impair cognitive function. Finally, a model is described proposing that Western diet consumption contributes to the development of excessive food intake and obesity, in part, by interfering with a type of hippocampal-dependent memory inhibition that is critical in the ability of animals to refrain from responding to environmental cues associated with food, and ultimately from consuming energy intake in excess of that driven solely by caloric need. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/21167850/Western_diet_consumption_and_cognitive_impairment:_links_to_hippocampal_dysfunction_and_obesity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(10)00450-6 DB - PRIME DP - Unbound Medicine ER -