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Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: a case-control study in Japan.
Parkinsonism Relat Disord 2011; 17(2):112-6PR

Abstract

Three previous cohort studies in the USA reported that dairy product consumption was significantly associated with an increased risk of Parkinson's disease (PD) in men, but not in women. We examined the relationship between consumption of dairy products, calcium, and vitamin D and the risk of PD using data from a multicenter hospital-based case-control study in Japan. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Adjustment was made for sex, age, region of residence, pack-years of smoking, years of education, body mass index, and dietary factors including cholesterol, dietary glycemic index, vitamin E, β-carotene, vitamin B(6), caffeine, iron, and alcohol. Total dairy product consumption was not materially associated with the risk of PD (P for trend = 0.62). No evident relationships were observed between intake of milk, yogurt, cheese, or ice cream and the risk of PD (P for trend = 0.75, 0.63, 0.59, and 0.35, respectively). There were no measurable associations between consumption of calcium or vitamin D and PD (P for trend = 0.37 and 0.69, respectively). No significant interactions were observed between the dietary exposures and sex regarding PD. Our results suggest that intake of dairy products, calcium, and vitamin D was not related to PD, regardless of sex. However, such null relationships might be a consequence of PD.

Authors+Show Affiliations

Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan. miyake-y@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21169048

Citation

Miyake, Y, et al. "Lack of Association of Dairy Food, Calcium, and Vitamin D Intake With the Risk of Parkinson's Disease: a Case-control Study in Japan." Parkinsonism & Related Disorders, vol. 17, no. 2, 2011, pp. 112-6.
Miyake Y, Tanaka K, Fukushima W, et al. Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: a case-control study in Japan. Parkinsonism Relat Disord. 2011;17(2):112-6.
Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., ... Nagai, M. (2011). Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: a case-control study in Japan. Parkinsonism & Related Disorders, 17(2), pp. 112-6. doi:10.1016/j.parkreldis.2010.11.018.
Miyake Y, et al. Lack of Association of Dairy Food, Calcium, and Vitamin D Intake With the Risk of Parkinson's Disease: a Case-control Study in Japan. Parkinsonism Relat Disord. 2011;17(2):112-6. PubMed PMID: 21169048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: a case-control study in Japan. AU - Miyake,Y, AU - Tanaka,K, AU - Fukushima,W, AU - Sasaki,S, AU - Kiyohara,C, AU - Tsuboi,Y, AU - Yamada,T, AU - Oeda,T, AU - Miki,T, AU - Kawamura,N, AU - Sakae,N, AU - Fukuyama,H, AU - Hirota,Y, AU - Nagai,M, AU - ,, Y1 - 2010/12/18/ PY - 2010/09/22/received PY - 2010/11/13/revised PY - 2010/11/24/accepted PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/12/14/medline SP - 112 EP - 6 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 17 IS - 2 N2 - Three previous cohort studies in the USA reported that dairy product consumption was significantly associated with an increased risk of Parkinson's disease (PD) in men, but not in women. We examined the relationship between consumption of dairy products, calcium, and vitamin D and the risk of PD using data from a multicenter hospital-based case-control study in Japan. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Adjustment was made for sex, age, region of residence, pack-years of smoking, years of education, body mass index, and dietary factors including cholesterol, dietary glycemic index, vitamin E, β-carotene, vitamin B(6), caffeine, iron, and alcohol. Total dairy product consumption was not materially associated with the risk of PD (P for trend = 0.62). No evident relationships were observed between intake of milk, yogurt, cheese, or ice cream and the risk of PD (P for trend = 0.75, 0.63, 0.59, and 0.35, respectively). There were no measurable associations between consumption of calcium or vitamin D and PD (P for trend = 0.37 and 0.69, respectively). No significant interactions were observed between the dietary exposures and sex regarding PD. Our results suggest that intake of dairy products, calcium, and vitamin D was not related to PD, regardless of sex. However, such null relationships might be a consequence of PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/21169048/Lack_of_association_of_dairy_food_calcium_and_vitamin_D_intake_with_the_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(10)00298-1 DB - PRIME DP - Unbound Medicine ER -