Tags

Type your tag names separated by a space and hit enter

Formulation and in vitro characterization of spray dried microspheres of amoxicillin.
Acta Pharm. 2010 Dec; 60(4):455-65.AP

Abstract

The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and in vitro drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutaraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres.

Authors+Show Affiliations

S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway Kherva, Gujarat, India. jignyasha26@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21169137

Citation

Raval, Jignyasha A., et al. "Formulation and in Vitro Characterization of Spray Dried Microspheres of Amoxicillin." Acta Pharmaceutica (Zagreb, Croatia), vol. 60, no. 4, 2010, pp. 455-65.
Raval JA, Patel JK, Patel MM. Formulation and in vitro characterization of spray dried microspheres of amoxicillin. Acta Pharm. 2010;60(4):455-65.
Raval, J. A., Patel, J. K., & Patel, M. M. (2010). Formulation and in vitro characterization of spray dried microspheres of amoxicillin. Acta Pharmaceutica (Zagreb, Croatia), 60(4), 455-65. https://doi.org/10.2478/v10007-010-0034-7
Raval JA, Patel JK, Patel MM. Formulation and in Vitro Characterization of Spray Dried Microspheres of Amoxicillin. Acta Pharm. 2010;60(4):455-65. PubMed PMID: 21169137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and in vitro characterization of spray dried microspheres of amoxicillin. AU - Raval,Jignyasha A, AU - Patel,Jayvadan K, AU - Patel,Madhabhai M, PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/6/22/medline SP - 455 EP - 65 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 60 IS - 4 N2 - The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and in vitro drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutaraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres. SN - 1846-9558 UR - https://www.unboundmedicine.com/medline/citation/21169137/Formulation_and_in_vitro_characterization_of_spray_dried_microspheres_of_amoxicillin_ L2 - https://www.degruyter.com/doi/10.2478/v10007-010-0034-7 DB - PRIME DP - Unbound Medicine ER -