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A preliminary study on the role of inherited prothrombotic risk factors in Taiwanese patients with sudden sensorineural hearing loss.
Eur Arch Otorhinolaryngol 2011; 268(6):817-22EA

Abstract

Sudden sensorineural hearing loss (SSHL) is a disease with unknown etiology. Recently, several studies revealed that some inherited prothrombotic risk factors are associated with SSHL in western populations. The objective of this study was to investigate the roles of the two most common genetic prothrombotic factors, the factor V Leiden G1691A and prothrombin G20210A in Taiwanese patients with SSHL. Twenty-four patients diagnosed with SSHL of more than 30 dB on average pure tone audiometry (PTA) and thirty-six healthy subjects without a history of hearing loss were enrolled in this study. Genomic DNA was isolated from peripheral blood leukocytes and the single nucleotide polymorphisms (SNPs) genotyping of factor V Leiden G1691A and prothrombin G20210A were analyzed using the TaqMan genotyping assays. Neither factor V Leiden G1691A nor prothrombin G20210A was detected in SSHL patients or in the control subjects. Both the patient group and the control group exhibited wild-type V Leiden 1691GG and wild-type prothrombin 20210GG. In conclusion, the factors V Leiden G1691A and prothrombin G20210A do not seem to play any role in Taiwanese patients with SSHL. Further studies with a large series of patients are needed to identify other possible candidate genes in order to elucidate the pathogenesis of SSHL.

Authors+Show Affiliations

Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21170721

Citation

Lan, Ming-Ying, et al. "A Preliminary Study On the Role of Inherited Prothrombotic Risk Factors in Taiwanese Patients With Sudden Sensorineural Hearing Loss." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 268, no. 6, 2011, pp. 817-22.
Lan MY, Shiao JY, Hsu YB, et al. A preliminary study on the role of inherited prothrombotic risk factors in Taiwanese patients with sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 2011;268(6):817-22.
Lan, M. Y., Shiao, J. Y., Hsu, Y. B., Lin, F. Y., & Lin, J. C. (2011). A preliminary study on the role of inherited prothrombotic risk factors in Taiwanese patients with sudden sensorineural hearing loss. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 268(6), pp. 817-22. doi:10.1007/s00405-010-1457-y.
Lan MY, et al. A Preliminary Study On the Role of Inherited Prothrombotic Risk Factors in Taiwanese Patients With Sudden Sensorineural Hearing Loss. Eur Arch Otorhinolaryngol. 2011;268(6):817-22. PubMed PMID: 21170721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A preliminary study on the role of inherited prothrombotic risk factors in Taiwanese patients with sudden sensorineural hearing loss. AU - Lan,Ming-Ying, AU - Shiao,Jiun-Yih, AU - Hsu,Yen-Bin, AU - Lin,Feng-Yi, AU - Lin,Jin-Ching, Y1 - 2010/12/19/ PY - 2010/08/05/received PY - 2010/12/01/accepted PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/11/16/medline SP - 817 EP - 22 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 268 IS - 6 N2 - Sudden sensorineural hearing loss (SSHL) is a disease with unknown etiology. Recently, several studies revealed that some inherited prothrombotic risk factors are associated with SSHL in western populations. The objective of this study was to investigate the roles of the two most common genetic prothrombotic factors, the factor V Leiden G1691A and prothrombin G20210A in Taiwanese patients with SSHL. Twenty-four patients diagnosed with SSHL of more than 30 dB on average pure tone audiometry (PTA) and thirty-six healthy subjects without a history of hearing loss were enrolled in this study. Genomic DNA was isolated from peripheral blood leukocytes and the single nucleotide polymorphisms (SNPs) genotyping of factor V Leiden G1691A and prothrombin G20210A were analyzed using the TaqMan genotyping assays. Neither factor V Leiden G1691A nor prothrombin G20210A was detected in SSHL patients or in the control subjects. Both the patient group and the control group exhibited wild-type V Leiden 1691GG and wild-type prothrombin 20210GG. In conclusion, the factors V Leiden G1691A and prothrombin G20210A do not seem to play any role in Taiwanese patients with SSHL. Further studies with a large series of patients are needed to identify other possible candidate genes in order to elucidate the pathogenesis of SSHL. SN - 1434-4726 UR - https://www.unboundmedicine.com/medline/citation/21170721/A_preliminary_study_on_the_role_of_inherited_prothrombotic_risk_factors_in_Taiwanese_patients_with_sudden_sensorineural_hearing_loss_ L2 - https://dx.doi.org/10.1007/s00405-010-1457-y DB - PRIME DP - Unbound Medicine ER -