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Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery.
J Biomed Mater Res A 2011; 96(2):330-40JB

Abstract

Novel micelles from biamphiphilic triblock copolymer poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(acrylic acid) (PEG-b-PCL-b-PAA) as new multifunctional nanocarriers to delivery anticancer drugs were evaluated. The well-defined triblock copolymers prepared by controlled polymerizations self-assembled into micelles in aqueous solution with a hydrodynamic radius of 13 nm as obtained by dynamic light scattering (DLS) and a low critical micellization concentration of 2.9 × 10(-4) g/L. The hydrophobic PCL cores of micelles were applied to load hydrophobic drug doxorubicin and the functional PAA subcoronas clung to the micellar core were used to carry cisplatin through covalent interaction. The results indicated that two anticancer drugs had been loaded by different mechanism either separately or simultaneously. Drug loading content and efficiency as well as release profiles were evaluated. Furthermore, internalization and cytotoxicity of the anticancer nanoparticles against human bladder carcinoma EJ cells were studied. The biamphiphilic triblock copolymer micelles provided not only biocompatibility and biodegradability, but also abilities for loading single and dual anticancer drugs, indicating that this was a useful multifunctional platform for anticancer drug delivery.

Authors+Show Affiliations

Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21171152

Citation

Zhu, Wen, et al. "Biamphiphilic Triblock Copolymer Micelles as a Multifunctional Platform for Anticancer Drug Delivery." Journal of Biomedical Materials Research. Part A, vol. 96, no. 2, 2011, pp. 330-40.
Zhu W, Li Y, Liu L, et al. Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery. J Biomed Mater Res A. 2011;96(2):330-40.
Zhu, W., Li, Y., Liu, L., Zhang, W., Chen, Y., & Xi, F. (2011). Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery. Journal of Biomedical Materials Research. Part A, 96(2), pp. 330-40. doi:10.1002/jbm.a.32985.
Zhu W, et al. Biamphiphilic Triblock Copolymer Micelles as a Multifunctional Platform for Anticancer Drug Delivery. J Biomed Mater Res A. 2011;96(2):330-40. PubMed PMID: 21171152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery. AU - Zhu,Wen, AU - Li,Yanli, AU - Liu,Lixin, AU - Zhang,Wenlong, AU - Chen,Yongming, AU - Xi,Fu, Y1 - 2010/11/29/ PY - 2010/06/09/received PY - 2010/09/02/revised PY - 2010/09/28/accepted PY - 2010/12/21/entrez PY - 2010/12/21/pubmed PY - 2011/3/29/medline SP - 330 EP - 40 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 96 IS - 2 N2 - Novel micelles from biamphiphilic triblock copolymer poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(acrylic acid) (PEG-b-PCL-b-PAA) as new multifunctional nanocarriers to delivery anticancer drugs were evaluated. The well-defined triblock copolymers prepared by controlled polymerizations self-assembled into micelles in aqueous solution with a hydrodynamic radius of 13 nm as obtained by dynamic light scattering (DLS) and a low critical micellization concentration of 2.9 × 10(-4) g/L. The hydrophobic PCL cores of micelles were applied to load hydrophobic drug doxorubicin and the functional PAA subcoronas clung to the micellar core were used to carry cisplatin through covalent interaction. The results indicated that two anticancer drugs had been loaded by different mechanism either separately or simultaneously. Drug loading content and efficiency as well as release profiles were evaluated. Furthermore, internalization and cytotoxicity of the anticancer nanoparticles against human bladder carcinoma EJ cells were studied. The biamphiphilic triblock copolymer micelles provided not only biocompatibility and biodegradability, but also abilities for loading single and dual anticancer drugs, indicating that this was a useful multifunctional platform for anticancer drug delivery. SN - 1552-4965 UR - https://www.unboundmedicine.com/medline/citation/21171152/Biamphiphilic_triblock_copolymer_micelles_as_a_multifunctional_platform_for_anticancer_drug_delivery_ L2 - https://doi.org/10.1002/jbm.a.32985 DB - PRIME DP - Unbound Medicine ER -