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[Frusemide plus doxazosin therapy for nocturia in patients with BPH/LUTS].
Zhonghua Nan Ke Xue. 2010 Sep; 16(9):807-10.ZN

Abstract

OBJECTIVE

To determine the efficacy and safety of a diuretic agent, frusemide, combined with doxazosin in the treatment of nocturia in patients with benign prostate hyperplasia / lower urinary tract symptoms (BPH/LUTS).

METHODS

Sixty-four BPH/LUTS patients with nocturia were equally randomized into two groups, one treated with doxazosin (4 mg/d), and the other with frusemide (40 mg/d) and doxazosin (4 mg/d), given 6 h before sleep, both for 4 weeks. Urine volume, IPSS, QOL, serum electrolytes, plasma osmolality were recorded and compared between the two groups before and after the treatment.

RESULTS

Compared with the doxazosin group, the frusemide plus doxazosin group showed significantly reduced nocturia frequency (P < 0.01), increased daytime urine output (P < 0.01), decreased nocturia urine output (P < 0.01), unchanged total urine output (P > 0.05), improved IPSS and QOL (P < 0.05, P < 0.01), but with no remarkable differences in the levels of serum sodium, potassium, chlorine, and osmotic pressure (P > 0.05).

CONCLUSION

Four-week treatment with frusemide plus doxazosin was safe and effective for nocturia in patients with BPH/LUTS.

Authors+Show Affiliations

Department of Urology, Union Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350001, China. monkeytreeh4y@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

21171265

Citation

Huang, Shi-yong, et al. "[Frusemide Plus Doxazosin Therapy for Nocturia in Patients With BPH/LUTS]." Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 16, no. 9, 2010, pp. 807-10.
Huang SY, Zhu SX, Zeng BW, et al. [Frusemide plus doxazosin therapy for nocturia in patients with BPH/LUTS]. Zhonghua Nan Ke Xue. 2010;16(9):807-10.
Huang, S. Y., Zhu, S. X., Zeng, B. W., Zhu, D. S., & Fang, R. J. (2010). [Frusemide plus doxazosin therapy for nocturia in patients with BPH/LUTS]. Zhonghua Nan Ke Xue = National Journal of Andrology, 16(9), 807-10.
Huang SY, et al. [Frusemide Plus Doxazosin Therapy for Nocturia in Patients With BPH/LUTS]. Zhonghua Nan Ke Xue. 2010;16(9):807-10. PubMed PMID: 21171265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Frusemide plus doxazosin therapy for nocturia in patients with BPH/LUTS]. AU - Huang,Shi-yong, AU - Zhu,Shao-xing, AU - Zeng,Bang-wei, AU - Zhu,De-sheng, AU - Fang,Rong-jin, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/11/16/medline SP - 807 EP - 10 JF - Zhonghua nan ke xue = National journal of andrology JO - Zhonghua Nan Ke Xue VL - 16 IS - 9 N2 - OBJECTIVE: To determine the efficacy and safety of a diuretic agent, frusemide, combined with doxazosin in the treatment of nocturia in patients with benign prostate hyperplasia / lower urinary tract symptoms (BPH/LUTS). METHODS: Sixty-four BPH/LUTS patients with nocturia were equally randomized into two groups, one treated with doxazosin (4 mg/d), and the other with frusemide (40 mg/d) and doxazosin (4 mg/d), given 6 h before sleep, both for 4 weeks. Urine volume, IPSS, QOL, serum electrolytes, plasma osmolality were recorded and compared between the two groups before and after the treatment. RESULTS: Compared with the doxazosin group, the frusemide plus doxazosin group showed significantly reduced nocturia frequency (P < 0.01), increased daytime urine output (P < 0.01), decreased nocturia urine output (P < 0.01), unchanged total urine output (P > 0.05), improved IPSS and QOL (P < 0.05, P < 0.01), but with no remarkable differences in the levels of serum sodium, potassium, chlorine, and osmotic pressure (P > 0.05). CONCLUSION: Four-week treatment with frusemide plus doxazosin was safe and effective for nocturia in patients with BPH/LUTS. SN - 1009-3591 UR - https://www.unboundmedicine.com/medline/citation/21171265/[Frusemide_plus_doxazosin_therapy_for_nocturia_in_patients_with_BPH/LUTS]_ L2 - https://medlineplus.gov/enlargedprostatebph.html DB - PRIME DP - Unbound Medicine ER -