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Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility.
J Microencapsul. 2011; 28(1):74-81.JM

Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.

Authors+Show Affiliations

Medway School of Science, University of Greenwich, Chatham Maritime ME4 4TB, Kent, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21171818

Citation

Potta, Sriharsha Gupta, et al. "Preparation and Characterization of Ibuprofen Solid Lipid Nanoparticles With Enhanced Solubility." Journal of Microencapsulation, vol. 28, no. 1, 2011, pp. 74-81.
Potta SG, Minemi S, Nukala RK, et al. Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. J Microencapsul. 2011;28(1):74-81.
Potta, S. G., Minemi, S., Nukala, R. K., Peinado, C., Lamprou, D. A., Urquhart, A., & Douroumis, D. (2011). Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation, 28(1), 74-81. https://doi.org/10.3109/02652048.2010.529948
Potta SG, et al. Preparation and Characterization of Ibuprofen Solid Lipid Nanoparticles With Enhanced Solubility. J Microencapsul. 2011;28(1):74-81. PubMed PMID: 21171818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. AU - Potta,Sriharsha Gupta, AU - Minemi,Sriharsha, AU - Nukala,Ravi Kumar, AU - Peinado,Chairmane, AU - Lamprou,Dimitrios A, AU - Urquhart,Andrew, AU - Douroumis,D, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/4/9/medline SP - 74 EP - 81 JF - Journal of microencapsulation JO - J Microencapsul VL - 28 IS - 1 N2 - Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/21171818/Preparation_and_characterization_of_ibuprofen_solid_lipid_nanoparticles_with_enhanced_solubility_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652048.2010.529948 DB - PRIME DP - Unbound Medicine ER -