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Drug treatment of scrub typhus.
Trop Doct. 2011 Jan; 41(1):1-4.TD

Abstract

Scrub typhus is a vector-borne disease caused by the pathogen Orientia tsutsugamushi. We review the published literature for evidence on drug treatment in scrub typhus. Doxycycline has a proven efficacy in several trials and a meta-analysis, although resistance has been documented in parts of northern Thailand. Macrolides are equally efficacious and have less adverse effects, but they are expensive. Azithromycin is the recommended drug in pregnancy and for children. Rifampicin is effective in areas where doxycycline resistance is present. Quinolones have shown some degree of efficacy but the evidence is scant. Most clinical evidence on drug treatment is from cases of mild-to-moderate scrub typhus. Further study is needed on the efficacy of different antibiotics in the treatment of severe, life-threatening scrub typhus.

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Authors+Show Affiliations

Rajapakse S
Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka. senaka.ucfm@gmail.com
Rodrigo C
No affiliation info available
Fernando SD
No affiliation info available

MeSH

Anti-Bacterial AgentsAzithromycinChildClinical Trials as TopicDoxycyclineFemaleHumansMacrolidesOrientia tsutsugamushiPregnancyRifampinScrub TyphusTreatment Outcome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21172901

Citation

Rajapakse, Senaka, et al. "Drug Treatment of Scrub Typhus." Tropical Doctor, vol. 41, no. 1, 2011, pp. 1-4.
Rajapakse S, Rodrigo C, Fernando SD. Drug treatment of scrub typhus. Trop Doct. 2011;41(1):1-4.
Rajapakse, S., Rodrigo, C., & Fernando, S. D. (2011). Drug treatment of scrub typhus. Tropical Doctor, 41(1), 1-4. https://doi.org/10.1258/td.2010.100311
Rajapakse S, Rodrigo C, Fernando SD. Drug Treatment of Scrub Typhus. Trop Doct. 2011;41(1):1-4. PubMed PMID: 21172901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug treatment of scrub typhus. AU - Rajapakse,Senaka, AU - Rodrigo,Chaturaka, AU - Fernando,Sumadhya Deepika, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/4/13/medline SP - 1 EP - 4 JF - Tropical doctor JO - Trop Doct VL - 41 IS - 1 N2 - Scrub typhus is a vector-borne disease caused by the pathogen Orientia tsutsugamushi. We review the published literature for evidence on drug treatment in scrub typhus. Doxycycline has a proven efficacy in several trials and a meta-analysis, although resistance has been documented in parts of northern Thailand. Macrolides are equally efficacious and have less adverse effects, but they are expensive. Azithromycin is the recommended drug in pregnancy and for children. Rifampicin is effective in areas where doxycycline resistance is present. Quinolones have shown some degree of efficacy but the evidence is scant. Most clinical evidence on drug treatment is from cases of mild-to-moderate scrub typhus. Further study is needed on the efficacy of different antibiotics in the treatment of severe, life-threatening scrub typhus. SN - 1758-1133 UR - https://www.unboundmedicine.com/medline/citation/21172901/Drug_treatment_of_scrub_typhus_ L2 - https://journals.sagepub.com/doi/10.1258/td.2010.100311?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -