Tags

Type your tag names separated by a space and hit enter

Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study.
Arch Otolaryngol Head Neck Surg. 2010 Dec; 136(12):1219-25.AO

Abstract

OBJECTIVE

to report patterns of failure according to treatment modality, with an emphasis on the role of postoperative radiotherapy in patients with localized head and neck mucosal melanoma (HNMM) treated during a 28-year period in a multi-institutional setting.

DESIGN

retrospective review.

SETTING

french medical institutions.

PATIENTS

a total of 160 patients with nonmetastatic HNMM treated from 1980 through 2008.

INTERVENTIONS

treatment modality consisted of surgery alone (hereinafter, S group) (n = 82 patients) or with postoperative radiotherapy (hereinafter, SRT group) (n = 78). Patients and tumor characteristics were similar in the 2 groups. There was a nonsignificant trend (P = .11) for more locally advanced tumor stage (38.9%) in the SRT group compared with the S group (24.5%).

RESULTS

patients in the S group had an increased probability of locoregional recurrence as a first event (55.6%) compared with those in the SRT group (29.9%; P < .01). After adjusting for tumor stage (T1/T2 vs T3/T4), the subdistribution hazard ratio of locoregional relapse was 0.31, (95% confidence interval [CI], 0.15-0.61; P < .01).The rate of distant metastasis as a first event was significantly higher in the SRT group (40.6%) compared with the S group (19.9%; P = .01). Regardless of their treatment, patients who had a locoregional relapse during follow-up had an increased risk of subsequent distant metastasis (hazard ratio, 3.07; 95% CI, 1.65-5.67) and death (hazard ratio, 3.01; 95% CI, 1.91-4.78).

CONCLUSIONS

this large retrospective study suggests that postoperative radiotherapy improves the locoregional control of HNMM. The higher rate of distant metastasis was due to more advanced disease in the SRT group.

Authors+Show Affiliations

Department of Head and Neck Surgery, Claudius Regaud Institute, 20-24 rue du pont Saint Pierre, Toulouse 31052, France. adil.benlyazid@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

21173371

Citation

Benlyazid, Adil, et al. "Postoperative Radiotherapy in Head and Neck Mucosal Melanoma: a GETTEC Study." Archives of Otolaryngology--head & Neck Surgery, vol. 136, no. 12, 2010, pp. 1219-25.
Benlyazid A, Thariat J, Temam S, et al. Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study. Arch Otolaryngol Head Neck Surg. 2010;136(12):1219-25.
Benlyazid, A., Thariat, J., Temam, S., Malard, O., Florescu, C., Choussy, O., Makeieff, M., Poissonnet, G., Penel, N., Righini, C., Toussaint, B., Lacau St Guily, J., Vergez, S., & Filleron, T. (2010). Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study. Archives of Otolaryngology--head & Neck Surgery, 136(12), 1219-25. https://doi.org/10.1001/archoto.2010.217
Benlyazid A, et al. Postoperative Radiotherapy in Head and Neck Mucosal Melanoma: a GETTEC Study. Arch Otolaryngol Head Neck Surg. 2010;136(12):1219-25. PubMed PMID: 21173371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC study. AU - Benlyazid,Adil, AU - Thariat,Juliette, AU - Temam,Stephane, AU - Malard,Olivier, AU - Florescu,Carmen, AU - Choussy,Olivier, AU - Makeieff,Marc, AU - Poissonnet,Gilles, AU - Penel,Nicolas, AU - Righini,Christian, AU - Toussaint,Bruno, AU - Lacau St Guily,Jean, AU - Vergez,Sebastien, AU - Filleron,Thomas, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/3/16/medline SP - 1219 EP - 25 JF - Archives of otolaryngology--head & neck surgery JO - Arch Otolaryngol Head Neck Surg VL - 136 IS - 12 N2 - OBJECTIVE: to report patterns of failure according to treatment modality, with an emphasis on the role of postoperative radiotherapy in patients with localized head and neck mucosal melanoma (HNMM) treated during a 28-year period in a multi-institutional setting. DESIGN: retrospective review. SETTING: french medical institutions. PATIENTS: a total of 160 patients with nonmetastatic HNMM treated from 1980 through 2008. INTERVENTIONS: treatment modality consisted of surgery alone (hereinafter, S group) (n = 82 patients) or with postoperative radiotherapy (hereinafter, SRT group) (n = 78). Patients and tumor characteristics were similar in the 2 groups. There was a nonsignificant trend (P = .11) for more locally advanced tumor stage (38.9%) in the SRT group compared with the S group (24.5%). RESULTS: patients in the S group had an increased probability of locoregional recurrence as a first event (55.6%) compared with those in the SRT group (29.9%; P < .01). After adjusting for tumor stage (T1/T2 vs T3/T4), the subdistribution hazard ratio of locoregional relapse was 0.31, (95% confidence interval [CI], 0.15-0.61; P < .01).The rate of distant metastasis as a first event was significantly higher in the SRT group (40.6%) compared with the S group (19.9%; P = .01). Regardless of their treatment, patients who had a locoregional relapse during follow-up had an increased risk of subsequent distant metastasis (hazard ratio, 3.07; 95% CI, 1.65-5.67) and death (hazard ratio, 3.01; 95% CI, 1.91-4.78). CONCLUSIONS: this large retrospective study suggests that postoperative radiotherapy improves the locoregional control of HNMM. The higher rate of distant metastasis was due to more advanced disease in the SRT group. SN - 1538-361X UR - https://www.unboundmedicine.com/medline/citation/21173371/Postoperative_radiotherapy_in_head_and_neck_mucosal_melanoma:_a_GETTEC_study_ L2 - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/archoto.2010.217 DB - PRIME DP - Unbound Medicine ER -