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Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease.
Int Angiol 2010; 29(6):489-95IA

Abstract

AIM

The aim of the present study was to define the roles of trace elements and toxic heavy metals in Buerger disease and atherosclerotic peripheral arterial occlusive disease (PAOD).

METHODS

Seventy-five subjects who were identical in demographic charecteristics were selected for the study; 25 with Buerger disease, 25 with PAOD, 25 healthy volunteers. Serum selenium (Se), zinc (Zn), copper (Cu), iron (Fe),whole blood cadmium (Cd) and lead (Pb), erythrocyte glutathione (GSH), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte and plasma malondialdehyde (MDA) levels were measured.

RESULTS

Serum Se and Zn levels were significantly low in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively). Serum levels of Fe and Zn were also significantly low in patients with PAOD compared to controls (p<0.001 and p<0.05 respectively). In contrast, Cu and Pb levels in Buerger disease group were significantly high compared to PAOD and control groups (P<0.001 and P<0.001 respectively). Erythrocyte GSH and GSH-Px levels were significantly lower in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively), while erythrocyte and plasma MDA levels were significantly higher (P<0.001 and P<0.001 respectively).

CONCLUSION

It can be concluded that the levels of trace elments and toxic heavy metals and oxidative stress influence the disease process in Buerger disease more than PAOD.

Authors+Show Affiliations

Cardiovascular Surgery Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. canerkvc@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21173730

Citation

Arslan, C, et al. "Trace Elements and Toxic Heavy Metals Play a Role in Buerger Disease and Atherosclerotic Peripheral Arterial Occlusive Disease." International Angiology : a Journal of the International Union of Angiology, vol. 29, no. 6, 2010, pp. 489-95.
Arslan C, Altan H, Akgün OO, et al. Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease. Int Angiol. 2010;29(6):489-95.
Arslan, C., Altan, H., Akgün, O. O., Kiziler, A. R., Aydemir, B., Güzel, S., ... Bozkurt, A. K. (2010). Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease. International Angiology : a Journal of the International Union of Angiology, 29(6), pp. 489-95.
Arslan C, et al. Trace Elements and Toxic Heavy Metals Play a Role in Buerger Disease and Atherosclerotic Peripheral Arterial Occlusive Disease. Int Angiol. 2010;29(6):489-95. PubMed PMID: 21173730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease. AU - Arslan,C, AU - Altan,H, AU - Akgün,O O, AU - Kiziler,A R, AU - Aydemir,B, AU - Güzel,S, AU - Besirli,K, AU - Bozkurt,A K, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/4/26/medline SP - 489 EP - 95 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 29 IS - 6 N2 - AIM: The aim of the present study was to define the roles of trace elements and toxic heavy metals in Buerger disease and atherosclerotic peripheral arterial occlusive disease (PAOD). METHODS: Seventy-five subjects who were identical in demographic charecteristics were selected for the study; 25 with Buerger disease, 25 with PAOD, 25 healthy volunteers. Serum selenium (Se), zinc (Zn), copper (Cu), iron (Fe),whole blood cadmium (Cd) and lead (Pb), erythrocyte glutathione (GSH), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte and plasma malondialdehyde (MDA) levels were measured. RESULTS: Serum Se and Zn levels were significantly low in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively). Serum levels of Fe and Zn were also significantly low in patients with PAOD compared to controls (p<0.001 and p<0.05 respectively). In contrast, Cu and Pb levels in Buerger disease group were significantly high compared to PAOD and control groups (P<0.001 and P<0.001 respectively). Erythrocyte GSH and GSH-Px levels were significantly lower in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively), while erythrocyte and plasma MDA levels were significantly higher (P<0.001 and P<0.001 respectively). CONCLUSION: It can be concluded that the levels of trace elments and toxic heavy metals and oxidative stress influence the disease process in Buerger disease more than PAOD. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/21173730/Trace_elements_and_toxic_heavy_metals_play_a_role_in_Buerger_disease_and_atherosclerotic_peripheral_arterial_occlusive_disease_ L2 - http://www.minervamedica.it/index2.t?show=R34Y2010N06A0489 DB - PRIME DP - Unbound Medicine ER -