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Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study).
Int Angiol. 2010 Dec; 29(6):525-32.IA

Abstract

AIM

The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients.

METHODS

This study is an observational, single arm, multicentric and prospective trial. Patients suffering from CVD and belonging to C0s-C3 Clinical Etiological Anatomical and Physiopathological (CEAP) classes were included. Patient profiles, risk factors, clinical symptomatology and quality of life (QoL) assessed by SF-12 and CIVIQ questionnaires were evaluated at inclusion and after 12-week treatment.

RESULTS

The main factors influencing the previous management of patients were age, gender, body mass index (BMI), familial history, physical activity, exposure to heat, heavy loads lifting, profession and clinical characteristics. All clinical symptoms significantly improved with treatment and, as BMI and CEAP classes increased. Ankle circumferences decreased over time, correlating with BMI and CEAP classes. The physical and psychological dimensions of the SF-12 score significantly increased over time and improved within each CEAP class. The CIVIQ score significantly improved over time, correlating with age and CEAP classes.

CONCLUSION

A 12-week treatment with Ruscus aculeatus HMC-AA showed a significant decrease in the clinical symptoms and a significant improvement in the QoL of patients with CVD.

Authors+Show Affiliations

Cabinet de Phlébologie, 32 Boulevard Dubouchage, Nice, France. jj.guex@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

21173734

Citation

Guex, J J., et al. "Quality of Life Improvement in Latin American Patients Suffering From Chronic Venous Disorder Using a Combination of Ruscus Aculeatus and Hesperidin Methyl-chalcone and Ascorbic Acid (quality Study)." International Angiology : a Journal of the International Union of Angiology, vol. 29, no. 6, 2010, pp. 525-32.
Guex JJ, Avril L, Enrici E, et al. Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study). Int Angiol. 2010;29(6):525-32.
Guex, J. J., Avril, L., Enrici, E., Enriquez, E., Lis, C., & Taïeb, C. (2010). Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study). International Angiology : a Journal of the International Union of Angiology, 29(6), 525-32.
Guex JJ, et al. Quality of Life Improvement in Latin American Patients Suffering From Chronic Venous Disorder Using a Combination of Ruscus Aculeatus and Hesperidin Methyl-chalcone and Ascorbic Acid (quality Study). Int Angiol. 2010;29(6):525-32. PubMed PMID: 21173734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study). AU - Guex,J J, AU - Avril,L, AU - Enrici,E, AU - Enriquez,E, AU - Lis,C, AU - Taïeb,C, PY - 2010/12/22/entrez PY - 2010/12/22/pubmed PY - 2011/4/26/medline SP - 525 EP - 32 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 29 IS - 6 N2 - AIM: The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients. METHODS: This study is an observational, single arm, multicentric and prospective trial. Patients suffering from CVD and belonging to C0s-C3 Clinical Etiological Anatomical and Physiopathological (CEAP) classes were included. Patient profiles, risk factors, clinical symptomatology and quality of life (QoL) assessed by SF-12 and CIVIQ questionnaires were evaluated at inclusion and after 12-week treatment. RESULTS: The main factors influencing the previous management of patients were age, gender, body mass index (BMI), familial history, physical activity, exposure to heat, heavy loads lifting, profession and clinical characteristics. All clinical symptoms significantly improved with treatment and, as BMI and CEAP classes increased. Ankle circumferences decreased over time, correlating with BMI and CEAP classes. The physical and psychological dimensions of the SF-12 score significantly increased over time and improved within each CEAP class. The CIVIQ score significantly improved over time, correlating with age and CEAP classes. CONCLUSION: A 12-week treatment with Ruscus aculeatus HMC-AA showed a significant decrease in the clinical symptoms and a significant improvement in the QoL of patients with CVD. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/21173734/Quality_of_life_improvement_in_Latin_American_patients_suffering_from_chronic_venous_disorder_using_a_combination_of_Ruscus_aculeatus_and_hesperidin_methyl_chalcone_and_ascorbic_acid__quality_study__ L2 - http://www.minervamedica.it/index2.t?show=R34Y2010N06A0525 DB - PRIME DP - Unbound Medicine ER -