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Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in asian indians.
Diabetes Technol Ther 2011; 13(1):19-25DT

Abstract

BACKGROUND

this study examined the association of -866G/A, Ala55Val, 45bpI/D, and -55C/T polymorphisms at the uncoupling protein (UCP) 3-2 loci with type 2 diabetes in Asian Indians.

METHODS

a case-control study was performed among 1,406 unrelated subjects (487 with type 2 diabetes and 919 normal glucose-tolerant [NGT]), chosen from the Chennai Urban Rural Epidemiology Study, an ongoing population-based study in Southern India. The polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Haplotype frequencies were estimated using an expectation-maximization algorithm. Linkage disequilibrium was estimated from the estimates of haplotypic frequencies.

RESULTS

the genotype (P = 0.00006) and the allele (P = 0.00007) frequencies of Ala55Val of the UCP2 gene showed a significant protective effect against the development of type 2 diabetes. The odds ratios (adjusted for age, sex, and body mass index) for diabetes for individuals carrying Ala/Val was 0.72, and that for individuals carrying Val/Val was 0.37. Homeostasis insulin resistance model assessment and 2-h plasma glucose were significantly lower among Val-allele carriers compared to the Ala/Ala genotype within the NGT group. The genotype (P = 0.02) and the allele (P = 0.002) frequencies of -55C/T of the UCP3 gene showed a significant protective effect against the development of diabetes. The odds ratio for diabetes for individuals carrying CT was 0.79, and that for individuals carrying TT was 0.61. The haplotype analyses further confirmed the association of Ala55Val with diabetes, where the haplotypes carrying the Ala allele were significantly higher in the cases compared to controls.

CONCLUSIONS

Ala55Val and -55C/T polymorphisms at the UCP3-2 loci are associated with a significantly reduced risk of developing type 2 diabetes in Asian Indians.

Authors+Show Affiliations

Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21175267

Citation

Vimaleswaran, Karani S., et al. "Uncoupling Protein 2 and 3 Gene Polymorphisms and Their Association With Type 2 Diabetes in Asian Indians." Diabetes Technology & Therapeutics, vol. 13, no. 1, 2011, pp. 19-25.
Vimaleswaran KS, Radha V, Ghosh S, et al. Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in asian indians. Diabetes Technol Ther. 2011;13(1):19-25.
Vimaleswaran, K. S., Radha, V., Ghosh, S., Majumder, P. P., Sathyanarayana Rao, M. R., & Mohan, V. (2011). Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in asian indians. Diabetes Technology & Therapeutics, 13(1), pp. 19-25. doi:10.1089/dia.2010.0091.
Vimaleswaran KS, et al. Uncoupling Protein 2 and 3 Gene Polymorphisms and Their Association With Type 2 Diabetes in Asian Indians. Diabetes Technol Ther. 2011;13(1):19-25. PubMed PMID: 21175267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in asian indians. AU - Vimaleswaran,Karani S, AU - Radha,Venkatesan, AU - Ghosh,Saurabh, AU - Majumder,Partha P, AU - Sathyanarayana Rao,Manchanahalli R, AU - Mohan,Viswanathan, PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/4/20/medline SP - 19 EP - 25 JF - Diabetes technology & therapeutics JO - Diabetes Technol. Ther. VL - 13 IS - 1 N2 - BACKGROUND: this study examined the association of -866G/A, Ala55Val, 45bpI/D, and -55C/T polymorphisms at the uncoupling protein (UCP) 3-2 loci with type 2 diabetes in Asian Indians. METHODS: a case-control study was performed among 1,406 unrelated subjects (487 with type 2 diabetes and 919 normal glucose-tolerant [NGT]), chosen from the Chennai Urban Rural Epidemiology Study, an ongoing population-based study in Southern India. The polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Haplotype frequencies were estimated using an expectation-maximization algorithm. Linkage disequilibrium was estimated from the estimates of haplotypic frequencies. RESULTS: the genotype (P = 0.00006) and the allele (P = 0.00007) frequencies of Ala55Val of the UCP2 gene showed a significant protective effect against the development of type 2 diabetes. The odds ratios (adjusted for age, sex, and body mass index) for diabetes for individuals carrying Ala/Val was 0.72, and that for individuals carrying Val/Val was 0.37. Homeostasis insulin resistance model assessment and 2-h plasma glucose were significantly lower among Val-allele carriers compared to the Ala/Ala genotype within the NGT group. The genotype (P = 0.02) and the allele (P = 0.002) frequencies of -55C/T of the UCP3 gene showed a significant protective effect against the development of diabetes. The odds ratio for diabetes for individuals carrying CT was 0.79, and that for individuals carrying TT was 0.61. The haplotype analyses further confirmed the association of Ala55Val with diabetes, where the haplotypes carrying the Ala allele were significantly higher in the cases compared to controls. CONCLUSIONS: Ala55Val and -55C/T polymorphisms at the UCP3-2 loci are associated with a significantly reduced risk of developing type 2 diabetes in Asian Indians. SN - 1557-8593 UR - https://www.unboundmedicine.com/medline/citation/21175267/Uncoupling_protein_2_and_3_gene_polymorphisms_and_their_association_with_type_2_diabetes_in_asian_indians_ L2 - https://www.liebertpub.com/doi/full/10.1089/dia.2010.0091?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -