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Hollow nitrogen-doped carbon microspheres pyrolyzed from self-polymerized dopamine and its application in simultaneous electrochemical determination of uric acid, ascorbic acid and dopamine.
Biosens Bioelectron. 2011 Feb 15; 26(6):2934-9.BB

Abstract

Hollow nitrogen-doped carbon microspheres (HNCMS) as a novel carbon material have been prepared and the catalytic activities of HNCMS-modified glassy carbon (GC) electrode towards the electro-oxidation of uric acid (UA), ascorbic acid (AA) and dopamine (DA) have also been investigated. Comparing with the bare GC and carbon nanotubes (CNTs) modified GC (CNTs/GC) electrodes, the HNCMS modified GC (HNCMS/GC) electrode has higher catalytic activities towards the oxidation of UA, AA and DA. Moreover, the peak separations between AA and DA, and DA and UA at the HNCMS/GC electrode are up to 212 and 136 mV, respectively, which are superior to those at the CNTs/GC electrode (168 and 114 mV). Thus the simultaneous determination of UA, AA and DA was carried out successfully. In the co-existence system of UA, AA and DA, the linear response range for UA, AA and DA are 5-30 μM, 100-1000 μM and 3-75 μM, respectively and the detection limits (S/N = 3) are 0.04 μM, 0.91 μM and 0.02 μM, respectively. Meanwhile, the HNCMS/GC electrode can be applied to measure uric acid in human urine, and may be useful for measuring abnormally high concentration of AA or DA. The attractive features of HNCMS provide potential applications in the simultaneous determination of UA, AA and DA.

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Authors+Show Affiliations

Xiao C
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Lushan Southern Road, Changsha 410082, PR China.
Chu X
No affiliation info available
Yang Y
No affiliation info available
Li X
No affiliation info available
Zhang X
No affiliation info available
Chen J
No affiliation info available

MeSH

Ascorbic AcidBiosensing TechniquesCarbonDopamineElectrochemical TechniquesHumansLimit of DetectionMicroscopy, Electron, ScanningMicrospheresNitrogenOxidation-ReductionPolymersUric Acid

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21177096

Citation

Xiao, Chunhui, et al. "Hollow Nitrogen-doped Carbon Microspheres Pyrolyzed From Self-polymerized Dopamine and Its Application in Simultaneous Electrochemical Determination of Uric Acid, Ascorbic Acid and Dopamine." Biosensors & Bioelectronics, vol. 26, no. 6, 2011, pp. 2934-9.
Xiao C, Chu X, Yang Y, et al. Hollow nitrogen-doped carbon microspheres pyrolyzed from self-polymerized dopamine and its application in simultaneous electrochemical determination of uric acid, ascorbic acid and dopamine. Biosens Bioelectron. 2011;26(6):2934-9.
Xiao, C., Chu, X., Yang, Y., Li, X., Zhang, X., & Chen, J. (2011). Hollow nitrogen-doped carbon microspheres pyrolyzed from self-polymerized dopamine and its application in simultaneous electrochemical determination of uric acid, ascorbic acid and dopamine. Biosensors & Bioelectronics, 26(6), 2934-9. https://doi.org/10.1016/j.bios.2010.11.041
Xiao C, et al. Hollow Nitrogen-doped Carbon Microspheres Pyrolyzed From Self-polymerized Dopamine and Its Application in Simultaneous Electrochemical Determination of Uric Acid, Ascorbic Acid and Dopamine. Biosens Bioelectron. 2011 Feb 15;26(6):2934-9. PubMed PMID: 21177096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hollow nitrogen-doped carbon microspheres pyrolyzed from self-polymerized dopamine and its application in simultaneous electrochemical determination of uric acid, ascorbic acid and dopamine. AU - Xiao,Chunhui, AU - Chu,Xiaochen, AU - Yang,Yan, AU - Li,Xing, AU - Zhang,Xiaohua, AU - Chen,Jinhua, Y1 - 2010/12/04/ PY - 2010/08/23/received PY - 2010/11/26/revised PY - 2010/11/26/accepted PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/5/5/medline SP - 2934 EP - 9 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 26 IS - 6 N2 - Hollow nitrogen-doped carbon microspheres (HNCMS) as a novel carbon material have been prepared and the catalytic activities of HNCMS-modified glassy carbon (GC) electrode towards the electro-oxidation of uric acid (UA), ascorbic acid (AA) and dopamine (DA) have also been investigated. Comparing with the bare GC and carbon nanotubes (CNTs) modified GC (CNTs/GC) electrodes, the HNCMS modified GC (HNCMS/GC) electrode has higher catalytic activities towards the oxidation of UA, AA and DA. Moreover, the peak separations between AA and DA, and DA and UA at the HNCMS/GC electrode are up to 212 and 136 mV, respectively, which are superior to those at the CNTs/GC electrode (168 and 114 mV). Thus the simultaneous determination of UA, AA and DA was carried out successfully. In the co-existence system of UA, AA and DA, the linear response range for UA, AA and DA are 5-30 μM, 100-1000 μM and 3-75 μM, respectively and the detection limits (S/N = 3) are 0.04 μM, 0.91 μM and 0.02 μM, respectively. Meanwhile, the HNCMS/GC electrode can be applied to measure uric acid in human urine, and may be useful for measuring abnormally high concentration of AA or DA. The attractive features of HNCMS provide potential applications in the simultaneous determination of UA, AA and DA. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/21177096/Hollow_nitrogen_doped_carbon_microspheres_pyrolyzed_from_self_polymerized_dopamine_and_its_application_in_simultaneous_electrochemical_determination_of_uric_acid_ascorbic_acid_and_dopamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(10)00807-9 DB - PRIME DP - Unbound Medicine ER -
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