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Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial.
Am J Clin Nutr. 2011 Mar; 93(3):516-24.AJ

Abstract

BACKGROUND

The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (≤20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women.

OBJECTIVE

We characterized long-term body-composition changes associated with the DM trial and potential modifiers of these associations.

DESIGN

In the DM trial, 48,835 women aged 50-79 y were randomly assigned to intervention (40%) or comparison (60%) groups. We studied a subset with whole-body dual-energy X-ray absorptiometry scans at baseline and during follow-up. Changes in fat mass (FM), lean mass (LM), and percentage body fat between the intervention (n = 1580) and comparison (n = 2731) groups at years 1, 3, and 6 were compared. By using generalized estimating equations, we calculated overall differences between groups and tested for interactions with age, diabetes, race-ethnicity (white, black, and Hispanic), body mass index (BMI), and hormone therapy (HT).

RESULTS

The intervention women experienced significantly greater reductions in percentage body fat, FM, and LM at years 1 and 3 than did women in the comparison group (all P < 0.05). At year 6, only the FM change was significantly different between groups. Overall, the intervention was associated with reductions in percentage body fat (-0.8%; 95% CI: -1.0%, -0.6%), FM (-1.1 kg; 95% CI: -1.3, -0.8 kg), and LM (-0.17 kg; 95% CI: -0.28, -0.06 kg) during follow-up (all P < 0.003). Intervention associations varied by race-ethnicity, BMI, diabetes, and HT and remained significant after adjustment for physical activity.

CONCLUSION

This intervention was associated with modest long-term body-composition changes; the findings were more robust in years 1 and 3. This trial was registered at clinicaltrials.gov as NCT00000611.

Authors+Show Affiliations

Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ccarty@whi.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21177798

Citation

Carty, Cara L., et al. "Low-fat Dietary Pattern and Change in Body-composition Traits in the Women's Health Initiative Dietary Modification Trial." The American Journal of Clinical Nutrition, vol. 93, no. 3, 2011, pp. 516-24.
Carty CL, Kooperberg C, Neuhouser ML, et al. Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. Am J Clin Nutr. 2011;93(3):516-24.
Carty, C. L., Kooperberg, C., Neuhouser, M. L., Tinker, L., Howard, B., Wactawski-Wende, J., Beresford, S. A., Snetselaar, L., Vitolins, M., Allison, M., Budrys, N., Prentice, R., & Peters, U. (2011). Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. The American Journal of Clinical Nutrition, 93(3), 516-24. https://doi.org/10.3945/ajcn.110.006395
Carty CL, et al. Low-fat Dietary Pattern and Change in Body-composition Traits in the Women's Health Initiative Dietary Modification Trial. Am J Clin Nutr. 2011;93(3):516-24. PubMed PMID: 21177798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. AU - Carty,Cara L, AU - Kooperberg,Charles, AU - Neuhouser,Marian L, AU - Tinker,Lesley, AU - Howard,Barbara, AU - Wactawski-Wende,Jean, AU - Beresford,Shirley A A, AU - Snetselaar,Linda, AU - Vitolins,Mara, AU - Allison,Matthew, AU - Budrys,Nicole, AU - Prentice,Ross, AU - Peters,Ulrike, Y1 - 2010/12/22/ PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/4/13/medline SP - 516 EP - 24 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 93 IS - 3 N2 - BACKGROUND: The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (≤20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women. OBJECTIVE: We characterized long-term body-composition changes associated with the DM trial and potential modifiers of these associations. DESIGN: In the DM trial, 48,835 women aged 50-79 y were randomly assigned to intervention (40%) or comparison (60%) groups. We studied a subset with whole-body dual-energy X-ray absorptiometry scans at baseline and during follow-up. Changes in fat mass (FM), lean mass (LM), and percentage body fat between the intervention (n = 1580) and comparison (n = 2731) groups at years 1, 3, and 6 were compared. By using generalized estimating equations, we calculated overall differences between groups and tested for interactions with age, diabetes, race-ethnicity (white, black, and Hispanic), body mass index (BMI), and hormone therapy (HT). RESULTS: The intervention women experienced significantly greater reductions in percentage body fat, FM, and LM at years 1 and 3 than did women in the comparison group (all P < 0.05). At year 6, only the FM change was significantly different between groups. Overall, the intervention was associated with reductions in percentage body fat (-0.8%; 95% CI: -1.0%, -0.6%), FM (-1.1 kg; 95% CI: -1.3, -0.8 kg), and LM (-0.17 kg; 95% CI: -0.28, -0.06 kg) during follow-up (all P < 0.003). Intervention associations varied by race-ethnicity, BMI, diabetes, and HT and remained significant after adjustment for physical activity. CONCLUSION: This intervention was associated with modest long-term body-composition changes; the findings were more robust in years 1 and 3. This trial was registered at clinicaltrials.gov as NCT00000611. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21177798/Low_fat_dietary_pattern_and_change_in_body_composition_traits_in_the_Women's_Health_Initiative_Dietary_Modification_Trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.110.006395 DB - PRIME DP - Unbound Medicine ER -