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Interferon interplay helps tissue cells to cope with SARS-coronavirus infection.
Virulence. 2010 Jul-Aug; 1(4):273-5.V

Abstract

SARS coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome, is a versatile pathogen armed with a host of factors countering the antiviral type I interferon (IFN) system. Hence, tissue cells infected with SARS-CoV are unable to launch an IFN response. Plasmacytoid dendritic cells, however, produce high levels of IFN after infection. We recently demonstrated that minute amounts of IFN applied before infection (IFN priming) can ameliorate the IFN response of tissue cells to SARS-CoV. IFN priming of SARS-CoV-infected cells activated genes for IFN transcription, IFN signaling, antiviral effector proteins, ubiquitinylation and ISGylation, antigen presentation, and other cytokines and chemokines, whereas IFN treatment or infection alone had no major effect. Thus, the IFN which is produced by plasmacytoid dendritic cells could enable tissue cells to at least partially overturn the SARS-CoV-induced block in innate immune activation.

Authors+Show Affiliations

Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Freiburg, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21178452

Citation

Kuri, Thomas, and Friedemann Weber. "Interferon Interplay Helps Tissue Cells to Cope With SARS-coronavirus Infection." Virulence, vol. 1, no. 4, 2010, pp. 273-5.
Kuri T, Weber F. Interferon interplay helps tissue cells to cope with SARS-coronavirus infection. Virulence. 2010;1(4):273-5.
Kuri, T., & Weber, F. (2010). Interferon interplay helps tissue cells to cope with SARS-coronavirus infection. Virulence, 1(4), 273-5. https://doi.org/10.4161/viru.1.4.11465
Kuri T, Weber F. Interferon Interplay Helps Tissue Cells to Cope With SARS-coronavirus Infection. Virulence. 2010 Jul-Aug;1(4):273-5. PubMed PMID: 21178452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interferon interplay helps tissue cells to cope with SARS-coronavirus infection. AU - Kuri,Thomas, AU - Weber,Friedemann, PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/4/20/medline SP - 273 EP - 5 JF - Virulence JO - Virulence VL - 1 IS - 4 N2 - SARS coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome, is a versatile pathogen armed with a host of factors countering the antiviral type I interferon (IFN) system. Hence, tissue cells infected with SARS-CoV are unable to launch an IFN response. Plasmacytoid dendritic cells, however, produce high levels of IFN after infection. We recently demonstrated that minute amounts of IFN applied before infection (IFN priming) can ameliorate the IFN response of tissue cells to SARS-CoV. IFN priming of SARS-CoV-infected cells activated genes for IFN transcription, IFN signaling, antiviral effector proteins, ubiquitinylation and ISGylation, antigen presentation, and other cytokines and chemokines, whereas IFN treatment or infection alone had no major effect. Thus, the IFN which is produced by plasmacytoid dendritic cells could enable tissue cells to at least partially overturn the SARS-CoV-induced block in innate immune activation. SN - 2150-5608 UR - https://www.unboundmedicine.com/medline/citation/21178452/Interferon_interplay_helps_tissue_cells_to_cope_with_SARS_coronavirus_infection_ L2 - http://www.tandfonline.com/doi/full/10.4161/viru.1.4.11465 DB - PRIME DP - Unbound Medicine ER -