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Nonalcoholic fatty liver disease in children.
Curr Opin Clin Nutr Metab Care. 2011 Mar; 14(2):151-7.CO

Abstract

PURPOSE OF REVIEW

Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease in children from the developed world. The purpose of this review is to provide both a focused overview of pediatric NAFLD as well as a summary of the most recent advancements in the field.

RECENT FINDINGS

Pediatric NAFLD is an underdiagnosed condition which can result in significant liver injury including cirrhosis. Although liver biopsy remains the standard for diagnosis and monitoring disease activity, several noninvasive biomarkers and imaging techniques hold significant promise. Dietary constituents, the intestinal bacterial flora, and sex hormones have been implicated as modulators of disease activity. NAFLD predisposition runs strongly in families and an allele in the PNPLA3 gene has shown a strong association with liver steatosis and hepatic inflammation. Treatment for pediatric NAFLD remains diet and exercise, but vitamin E may be a helpful adjunct.

SUMMARY

Pediatric NAFLD shares many features with its adult counterpart but is a distinct entity which requires independent investigation. Our understanding of NAFLD in terms of epidemiology and risk factors has improved considerably but significantly more investigation is required to unravel its pathophysiology and identify novel therapeutic targets.

Authors+Show Affiliations

Division of Pediatric Gastroenterology, Columbia University Medical Center, New York, New York, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21178608

Citation

Mencin, Ali A., and Joel E. Lavine. "Nonalcoholic Fatty Liver Disease in Children." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 14, no. 2, 2011, pp. 151-7.
Mencin AA, Lavine JE. Nonalcoholic fatty liver disease in children. Curr Opin Clin Nutr Metab Care. 2011;14(2):151-7.
Mencin, A. A., & Lavine, J. E. (2011). Nonalcoholic fatty liver disease in children. Current Opinion in Clinical Nutrition and Metabolic Care, 14(2), 151-7. https://doi.org/10.1097/MCO.0b013e328342baec
Mencin AA, Lavine JE. Nonalcoholic Fatty Liver Disease in Children. Curr Opin Clin Nutr Metab Care. 2011;14(2):151-7. PubMed PMID: 21178608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease in children. AU - Mencin,Ali A, AU - Lavine,Joel E, PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/3/22/medline SP - 151 EP - 7 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 14 IS - 2 N2 - PURPOSE OF REVIEW: Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease in children from the developed world. The purpose of this review is to provide both a focused overview of pediatric NAFLD as well as a summary of the most recent advancements in the field. RECENT FINDINGS: Pediatric NAFLD is an underdiagnosed condition which can result in significant liver injury including cirrhosis. Although liver biopsy remains the standard for diagnosis and monitoring disease activity, several noninvasive biomarkers and imaging techniques hold significant promise. Dietary constituents, the intestinal bacterial flora, and sex hormones have been implicated as modulators of disease activity. NAFLD predisposition runs strongly in families and an allele in the PNPLA3 gene has shown a strong association with liver steatosis and hepatic inflammation. Treatment for pediatric NAFLD remains diet and exercise, but vitamin E may be a helpful adjunct. SUMMARY: Pediatric NAFLD shares many features with its adult counterpart but is a distinct entity which requires independent investigation. Our understanding of NAFLD in terms of epidemiology and risk factors has improved considerably but significantly more investigation is required to unravel its pathophysiology and identify novel therapeutic targets. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/21178608/Nonalcoholic_fatty_liver_disease_in_children_ L2 - https://doi.org/10.1097/MCO.0b013e328342baec DB - PRIME DP - Unbound Medicine ER -