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Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia.
J Pediatr Hematol Oncol. 2011 Jan; 33(1):22-4.JP

Abstract

Lymphoid malignancies are rare in patients with Fanconi anemia (FA), particularly after bone marrow transplantation. A boy, who was diagnosed with FA at the age of 5; underwent successful bone marrow transplantation at the age of 11. One year later, he presented with fever and dry cough, and was found to have an anterior mediastinal tumor. Biopsy of the tumor revealed precursor-T cell lymphoblastic lymphoma. Human leukocyte antigen analysis confirmed that the tumor cells were derived from the patient's own cells. He received mild chemotherapy for lymphoma, but his condition deteriorated rapidly and he died from excessive chemotherapy-related toxicity. The literature contains no reports of successful chemotherapy for lymphoid tumors in patients with FA, and therefore, alternatives to chemotherapy should be considered in the treatment of such patients.

Authors+Show Affiliations

Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan. d-suzuki@chashu.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21178706

Citation

Suzuki, Daisuke, et al. "Precursor-T Lymphoblastic Lymphoma After Unrelated Bone Marrow Transplantation in a Patient With Fanconi Anemia." Journal of Pediatric Hematology/oncology, vol. 33, no. 1, 2011, pp. 22-4.
Suzuki D, Kobayashi R, Yasuda K, et al. Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia. J Pediatr Hematol Oncol. 2011;33(1):22-4.
Suzuki, D., Kobayashi, R., Yasuda, K., Nakagawa, A., Morimoto, T., Yabe, M., Yabe, H., & Kobayashi, K. (2011). Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia. Journal of Pediatric Hematology/oncology, 33(1), 22-4. https://doi.org/10.1097/MPH.0b013e3181eb3153
Suzuki D, et al. Precursor-T Lymphoblastic Lymphoma After Unrelated Bone Marrow Transplantation in a Patient With Fanconi Anemia. J Pediatr Hematol Oncol. 2011;33(1):22-4. PubMed PMID: 21178706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia. AU - Suzuki,Daisuke, AU - Kobayashi,Ryoji, AU - Yasuda,Kazue, AU - Nakagawa,Atsuko, AU - Morimoto,Tsuyoshi, AU - Yabe,Miharu, AU - Yabe,Hiromasa, AU - Kobayashi,Kunihiko, PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/2/22/medline SP - 22 EP - 4 JF - Journal of pediatric hematology/oncology JO - J Pediatr Hematol Oncol VL - 33 IS - 1 N2 - Lymphoid malignancies are rare in patients with Fanconi anemia (FA), particularly after bone marrow transplantation. A boy, who was diagnosed with FA at the age of 5; underwent successful bone marrow transplantation at the age of 11. One year later, he presented with fever and dry cough, and was found to have an anterior mediastinal tumor. Biopsy of the tumor revealed precursor-T cell lymphoblastic lymphoma. Human leukocyte antigen analysis confirmed that the tumor cells were derived from the patient's own cells. He received mild chemotherapy for lymphoma, but his condition deteriorated rapidly and he died from excessive chemotherapy-related toxicity. The literature contains no reports of successful chemotherapy for lymphoid tumors in patients with FA, and therefore, alternatives to chemotherapy should be considered in the treatment of such patients. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/21178706/Precursor_T_lymphoblastic_lymphoma_after_unrelated_bone_marrow_transplantation_in_a_patient_with_Fanconi_anemia_ L2 - https://doi.org/10.1097/MPH.0b013e3181eb3153 DB - PRIME DP - Unbound Medicine ER -