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Changes in serum antimüllerian hormone levels across the ovulatory menstrual cycle in late reproductive age.
Menopause. 2011 May; 18(5):521-4.M

Abstract

OBJECTIVE

The aim of this study was to assess the pattern of serum antimüllerian hormone (AMH) across the normal ovulatory menstrual cycle in women in late reproductive age when ovarian follicle reserve and, hence, serum AMH levels are reduced.

METHODS

Serum AMH levels were determined by enzyme-linked immunosorbent assay across the ovulatory menstrual cycle from women in mid (n = 18) and late (n = 43) reproductive life, including the menopausal transition.

RESULT

: No intracycle variation in AMH level was observed in women in mid reproductive life nor in 33% (n = 14) of women with normal ovulatory cycles in late reproductive age. In the remaining cycles, a significant 2-fold decrease (P < 0.01) in AMH in 11 cycles and a significant 4.2-fold increase (P < 0.01) in 10 cycles were observed between the follicular and luteal phases. In a further eight ovulatory cycles, AMH was below the level of assay detection. As ovarian follicle reserve decreases with age and AMH levels are reduced, separate patterns of AMH are detected in the follicular and luteal phases of ovulatory menstrual cycles, presumably reflecting the intermittent pattern of the emergence of follicles close to menopause.

CONCLUSIONS

It is concluded that when AMH levels are substantially reduced, as in late reproductive age, they become less reliable as markers of ovarian reserve because of the changing patterns observed in some cycles.

Authors+Show Affiliations

Prince Henry’s Institute, Monash Medical Centre, Clayton, Victoria, Australia. david.robertson@princehenrys.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21178792

Citation

Robertson, David M., et al. "Changes in Serum Antimüllerian Hormone Levels Across the Ovulatory Menstrual Cycle in Late Reproductive Age." Menopause (New York, N.Y.), vol. 18, no. 5, 2011, pp. 521-4.
Robertson DM, Hale GE, Fraser IS, et al. Changes in serum antimüllerian hormone levels across the ovulatory menstrual cycle in late reproductive age. Menopause. 2011;18(5):521-4.
Robertson, D. M., Hale, G. E., Fraser, I. S., Hughes, C. L., & Burger, H. G. (2011). Changes in serum antimüllerian hormone levels across the ovulatory menstrual cycle in late reproductive age. Menopause (New York, N.Y.), 18(5), 521-4. https://doi.org/10.1097/gme.0b013e3181f8d9e0
Robertson DM, et al. Changes in Serum Antimüllerian Hormone Levels Across the Ovulatory Menstrual Cycle in Late Reproductive Age. Menopause. 2011;18(5):521-4. PubMed PMID: 21178792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in serum antimüllerian hormone levels across the ovulatory menstrual cycle in late reproductive age. AU - Robertson,David M, AU - Hale,Georgina E, AU - Fraser,Ian S, AU - Hughes,Claude L, AU - Burger,Henry G, PY - 2010/12/24/entrez PY - 2010/12/24/pubmed PY - 2011/11/9/medline SP - 521 EP - 4 JF - Menopause (New York, N.Y.) JO - Menopause VL - 18 IS - 5 N2 - OBJECTIVE: The aim of this study was to assess the pattern of serum antimüllerian hormone (AMH) across the normal ovulatory menstrual cycle in women in late reproductive age when ovarian follicle reserve and, hence, serum AMH levels are reduced. METHODS: Serum AMH levels were determined by enzyme-linked immunosorbent assay across the ovulatory menstrual cycle from women in mid (n = 18) and late (n = 43) reproductive life, including the menopausal transition. RESULT: : No intracycle variation in AMH level was observed in women in mid reproductive life nor in 33% (n = 14) of women with normal ovulatory cycles in late reproductive age. In the remaining cycles, a significant 2-fold decrease (P < 0.01) in AMH in 11 cycles and a significant 4.2-fold increase (P < 0.01) in 10 cycles were observed between the follicular and luteal phases. In a further eight ovulatory cycles, AMH was below the level of assay detection. As ovarian follicle reserve decreases with age and AMH levels are reduced, separate patterns of AMH are detected in the follicular and luteal phases of ovulatory menstrual cycles, presumably reflecting the intermittent pattern of the emergence of follicles close to menopause. CONCLUSIONS: It is concluded that when AMH levels are substantially reduced, as in late reproductive age, they become less reliable as markers of ovarian reserve because of the changing patterns observed in some cycles. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/21178792/Changes_in_serum_antimüllerian_hormone_levels_across_the_ovulatory_menstrual_cycle_in_late_reproductive_age_ L2 - https://doi.org/10.1097/gme.0b013e3181f8d9e0 DB - PRIME DP - Unbound Medicine ER -