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Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
Sci China Life Sci. 2010 Dec; 53(12):1428-32.SC

Abstract

The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.

Authors+Show Affiliations

Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21181344

Citation

Chen, Shaohui, et al. "Endogenous Enkephalin Does Not Contribute to the Cerebral Anti-hyperalgesic Action of Gabapentin." Science China. Life Sciences, vol. 53, no. 12, 2010, pp. 1428-32.
Chen S, Zhao J, Huang Y, et al. Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin. Sci China Life Sci. 2010;53(12):1428-32.
Chen, S., Zhao, J., Huang, Y., Luo, A., Zuo, P., Yang, N., & Hao, W. (2010). Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin. Science China. Life Sciences, 53(12), 1428-32. https://doi.org/10.1007/s11427-010-4092-3
Chen S, et al. Endogenous Enkephalin Does Not Contribute to the Cerebral Anti-hyperalgesic Action of Gabapentin. Sci China Life Sci. 2010;53(12):1428-32. PubMed PMID: 21181344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin. AU - Chen,Shaohui, AU - Zhao,Jing, AU - Huang,Yuguang, AU - Luo,Ailun, AU - Zuo,Pingping, AU - Yang,Nan, AU - Hao,Wenyu, Y1 - 2010/12/23/ PY - 2010/03/20/received PY - 2010/06/28/accepted PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/3/29/medline SP - 1428 EP - 32 JF - Science China. Life sciences JO - Sci China Life Sci VL - 53 IS - 12 N2 - The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin. SN - 1869-1889 UR - https://www.unboundmedicine.com/medline/citation/21181344/Endogenous_enkephalin_does_not_contribute_to_the_cerebral_anti_hyperalgesic_action_of_gabapentin_ DB - PRIME DP - Unbound Medicine ER -