Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.Sci China Life Sci. 2010 Dec; 53(12):1428-32.SC
The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.