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Identification of capillary blood pressure levels at which capillary collapse is likely in a tissue subjected to large compressive and shear deformations.

Abstract

Pressure ulcers (PU) are localised damage to skin and underlying tissues, caused by sustained tissue deformations and ischaemia. PU typically appear in insensitive or immobile patients, e.g. those with spinal cord injury (SCI) or geriatric patients. As these patients often experience fluctuations in blood pressure, and are also exposed to high-shear loads in their weight-bearing soft tissues during wheelchair sitting or bed rest, we used an inverse finite element method to determine the effects of capillary blood pressure (CBP) and shear deformations on occurrence of mechanical collapse in capillaries. We studied collapse in straight, U-shaped and bifurcated capillaries. All model configurations were consistent in demonstrating that the level of CBP has a considerable influence on the likelihood of capillary collapse in the physiological CBP range, particularly if shear is present. Our modelling therefore suggests that low CBP is a 'suspect' risk factor for PU in SCI and geriatric patients.

Authors+Show Affiliations

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21181574

Citation

Shilo, Malka, and Amit Gefen. "Identification of Capillary Blood Pressure Levels at Which Capillary Collapse Is Likely in a Tissue Subjected to Large Compressive and Shear Deformations." Computer Methods in Biomechanics and Biomedical Engineering, vol. 15, no. 1, 2012, pp. 59-71.
Shilo M, Gefen A. Identification of capillary blood pressure levels at which capillary collapse is likely in a tissue subjected to large compressive and shear deformations. Comput Methods Biomech Biomed Engin. 2012;15(1):59-71.
Shilo, M., & Gefen, A. (2012). Identification of capillary blood pressure levels at which capillary collapse is likely in a tissue subjected to large compressive and shear deformations. Computer Methods in Biomechanics and Biomedical Engineering, 15(1), pp. 59-71. doi:10.1080/10255842.2010.539208.
Shilo M, Gefen A. Identification of Capillary Blood Pressure Levels at Which Capillary Collapse Is Likely in a Tissue Subjected to Large Compressive and Shear Deformations. Comput Methods Biomech Biomed Engin. 2012;15(1):59-71. PubMed PMID: 21181574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of capillary blood pressure levels at which capillary collapse is likely in a tissue subjected to large compressive and shear deformations. AU - Shilo,Malka, AU - Gefen,Amit, Y1 - 2011/09/09/ PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2012/5/19/medline SP - 59 EP - 71 JF - Computer methods in biomechanics and biomedical engineering JO - Comput Methods Biomech Biomed Engin VL - 15 IS - 1 N2 - Pressure ulcers (PU) are localised damage to skin and underlying tissues, caused by sustained tissue deformations and ischaemia. PU typically appear in insensitive or immobile patients, e.g. those with spinal cord injury (SCI) or geriatric patients. As these patients often experience fluctuations in blood pressure, and are also exposed to high-shear loads in their weight-bearing soft tissues during wheelchair sitting or bed rest, we used an inverse finite element method to determine the effects of capillary blood pressure (CBP) and shear deformations on occurrence of mechanical collapse in capillaries. We studied collapse in straight, U-shaped and bifurcated capillaries. All model configurations were consistent in demonstrating that the level of CBP has a considerable influence on the likelihood of capillary collapse in the physiological CBP range, particularly if shear is present. Our modelling therefore suggests that low CBP is a 'suspect' risk factor for PU in SCI and geriatric patients. SN - 1476-8259 UR - https://www.unboundmedicine.com/medline/citation/21181574/Identification_of_capillary_blood_pressure_levels_at_which_capillary_collapse_is_likely_in_a_tissue_subjected_to_large_compressive_and_shear_deformations_ L2 - http://www.tandfonline.com/doi/full/10.1080/10255842.2010.539208 DB - PRIME DP - Unbound Medicine ER -