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Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension.
Anaesthesia. 2010 Dec; 65(12):1200-5.A

Abstract

This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine. The incidence of hypotension was statistically similar in the two groups. However, in patients receiving phenylephrine, 7 (23%) developed bradycardia and 6 (20%), reactive hypertension. Neonatal outcome, in terms of Apgar scores and umbilical artery pH, was similar in both the groups. To conclude, phenylephrine and mephentermine infusions are equally effective in preventing post spinal hypotension in patients undergoing caesarean section and are associated with a similar neonatal outcome.

Authors+Show Affiliations

Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. medhamohta@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21182601

Citation

Mohta, M, et al. "Comparison of Phenylephrine Hydrochloride and Mephentermine Sulphate for Prevention of Post Spinal Hypotension." Anaesthesia, vol. 65, no. 12, 2010, pp. 1200-5.
Mohta M, Janani SS, Sethi AK, et al. Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. Anaesthesia. 2010;65(12):1200-5.
Mohta, M., Janani, S. S., Sethi, A. K., Agarwal, D., & Tyagi, A. (2010). Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. Anaesthesia, 65(12), 1200-5. https://doi.org/10.1111/j.1365-2044.2010.06559.x
Mohta M, et al. Comparison of Phenylephrine Hydrochloride and Mephentermine Sulphate for Prevention of Post Spinal Hypotension. Anaesthesia. 2010;65(12):1200-5. PubMed PMID: 21182601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. AU - Mohta,M, AU - Janani,S Sai, AU - Sethi,A K, AU - Agarwal,D, AU - Tyagi,A, PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/2/1/medline SP - 1200 EP - 5 JF - Anaesthesia JO - Anaesthesia VL - 65 IS - 12 N2 - This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine. The incidence of hypotension was statistically similar in the two groups. However, in patients receiving phenylephrine, 7 (23%) developed bradycardia and 6 (20%), reactive hypertension. Neonatal outcome, in terms of Apgar scores and umbilical artery pH, was similar in both the groups. To conclude, phenylephrine and mephentermine infusions are equally effective in preventing post spinal hypotension in patients undergoing caesarean section and are associated with a similar neonatal outcome. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/21182601/Comparison_of_phenylephrine_hydrochloride_and_mephentermine_sulphate_for_prevention_of_post_spinal_hypotension_ L2 - https://doi.org/10.1111/j.1365-2044.2010.06559.x DB - PRIME DP - Unbound Medicine ER -