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Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats.
J Ethnopharmacol. 2011 Mar 24; 134(2):294-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Cedrus deodara (Roxb.) Loud. is used in Ayurvedic medicine to treat peptic ulcer.

AIM OF THE STUDY

To evaluate the gastric antisecretory and antiulcer activity of Cedrus deodara.

MATERIALS AND METHODS

The volatile oil extracted by steam distillation of Cedrus deodara wood was examined for its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats.

RESULTS

The volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with Cedrus deodara significantly reduced the number of ulcer, ulcer score and ulcer index in pylorus-ligated and ethanol treated rats. The antiulcer activity of Cedrus deodara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation.

CONCLUSION

The present findings conclude that volatile oil of Cedrus deodara wood has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Shobhit University, NH-58, Modipuram, Meerut 250110, UP, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21182918

Citation

Kumar, Avadhesh, et al. "Gastric Antisecretory and Antiulcer Activities of Cedrus Deodara (Roxb.) Loud. in Wistar Rats." Journal of Ethnopharmacology, vol. 134, no. 2, 2011, pp. 294-7.
Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. J Ethnopharmacol. 2011;134(2):294-7.
Kumar, A., Singh, V., & Chaudhary, A. K. (2011). Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. Journal of Ethnopharmacology, 134(2), 294-7. https://doi.org/10.1016/j.jep.2010.12.019
Kumar A, Singh V, Chaudhary AK. Gastric Antisecretory and Antiulcer Activities of Cedrus Deodara (Roxb.) Loud. in Wistar Rats. J Ethnopharmacol. 2011 Mar 24;134(2):294-7. PubMed PMID: 21182918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. AU - Kumar,Avadhesh, AU - Singh,Vandana, AU - Chaudhary,Amrendra Kumar, Y1 - 2010/12/21/ PY - 2010/08/31/received PY - 2010/11/10/revised PY - 2010/12/10/accepted PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/11/8/medline SP - 294 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 134 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Cedrus deodara (Roxb.) Loud. is used in Ayurvedic medicine to treat peptic ulcer. AIM OF THE STUDY: To evaluate the gastric antisecretory and antiulcer activity of Cedrus deodara. MATERIALS AND METHODS: The volatile oil extracted by steam distillation of Cedrus deodara wood was examined for its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats. RESULTS: The volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with Cedrus deodara significantly reduced the number of ulcer, ulcer score and ulcer index in pylorus-ligated and ethanol treated rats. The antiulcer activity of Cedrus deodara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation. CONCLUSION: The present findings conclude that volatile oil of Cedrus deodara wood has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21182918/Gastric_antisecretory_and_antiulcer_activities_of_Cedrus_deodara__Roxb___Loud__in_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00895-0 DB - PRIME DP - Unbound Medicine ER -