Tags

Type your tag names separated by a space and hit enter

Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. in type 2 diabetic rats.
J Ethnopharmacol. 2011 Mar 24; 134(2):298-304.JE

Abstract

AIM

Symplocos cochinchinensis (Lour.) S. Moore. is used in Indian system of traditional medicine to treat diabetes mellitus. The present study aims to investigate the antidiabetic efficacy of the hexane extract of Symplocos cochinchinensis leaves in high fat diet-low streptozotocin (STZ) induced type 2 diabetic rats.

MATERIALS AND METHODS

The doses for the study were fixed based on Irwin test. The hypoglycemic effect of the hexane extract of Symplocos cochinchinensis leaves were studied in normal rats. Oral glucose and insulin tolerance tests were carried out. The antihyperglycemic effect of the hexane extract at 250 and 500 mg/kg was studied in high fat diet-low STZ induced type 2 diabetic rats for 28 days.

RESULTS

The extracts showed no adverse effects up to 5 g/kg concentration. In hypoglycemic study, after treatment with hexane extract at 250 and 500 mg/kg the blood glucose was mildly reduced. In oral glucose tolerance test, the treatment with the hexane extract at 250 and 500 mg/kg showed a highly significant reduction of 12.07% and 23.58% in plasma glucose levels, respectively 30 min after glucose load. The insulin tolerance test also showed improved insulin sensitivity after 60 min of insulin treatment. In high fat diet-low STZ induced type 2 diabetic rats, after 28 days treatment with the hexane extract at 250 and 500 mg/kg reduced the plasma glucose level by 17.04% and 42.10%, respectively. A significant reduction in plasma insulin, plasma and hepatic total cholesterol (TC), triglycerides (TG) and free fatty acids (FFA) and a significant increase in liver glycogen were observed in treated diabetic rats.

CONCLUSION

This study demonstrated the potential antidiabetic property of hexane extract of Symplocos cochinchinensis leaves on type 2 diabetes mellitus, thus justifying its traditional usage.

Authors+Show Affiliations

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21182925

Citation

Sunil, Christudas, et al. "Antidiabetic Effect of Symplocos Cochinchinensis (Lour.) S. Moore. in Type 2 Diabetic Rats." Journal of Ethnopharmacology, vol. 134, no. 2, 2011, pp. 298-304.
Sunil C, Ignacimuthu S, Agastian P. Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. in type 2 diabetic rats. J Ethnopharmacol. 2011;134(2):298-304.
Sunil, C., Ignacimuthu, S., & Agastian, P. (2011). Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. in type 2 diabetic rats. Journal of Ethnopharmacology, 134(2), 298-304. https://doi.org/10.1016/j.jep.2010.12.018
Sunil C, Ignacimuthu S, Agastian P. Antidiabetic Effect of Symplocos Cochinchinensis (Lour.) S. Moore. in Type 2 Diabetic Rats. J Ethnopharmacol. 2011 Mar 24;134(2):298-304. PubMed PMID: 21182925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. in type 2 diabetic rats. AU - Sunil,Christudas, AU - Ignacimuthu,Savarimuthu, AU - Agastian,Paul, Y1 - 2010/12/21/ PY - 2010/06/22/received PY - 2010/11/01/revised PY - 2010/12/14/accepted PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/11/8/medline SP - 298 EP - 304 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 134 IS - 2 N2 - AIM: Symplocos cochinchinensis (Lour.) S. Moore. is used in Indian system of traditional medicine to treat diabetes mellitus. The present study aims to investigate the antidiabetic efficacy of the hexane extract of Symplocos cochinchinensis leaves in high fat diet-low streptozotocin (STZ) induced type 2 diabetic rats. MATERIALS AND METHODS: The doses for the study were fixed based on Irwin test. The hypoglycemic effect of the hexane extract of Symplocos cochinchinensis leaves were studied in normal rats. Oral glucose and insulin tolerance tests were carried out. The antihyperglycemic effect of the hexane extract at 250 and 500 mg/kg was studied in high fat diet-low STZ induced type 2 diabetic rats for 28 days. RESULTS: The extracts showed no adverse effects up to 5 g/kg concentration. In hypoglycemic study, after treatment with hexane extract at 250 and 500 mg/kg the blood glucose was mildly reduced. In oral glucose tolerance test, the treatment with the hexane extract at 250 and 500 mg/kg showed a highly significant reduction of 12.07% and 23.58% in plasma glucose levels, respectively 30 min after glucose load. The insulin tolerance test also showed improved insulin sensitivity after 60 min of insulin treatment. In high fat diet-low STZ induced type 2 diabetic rats, after 28 days treatment with the hexane extract at 250 and 500 mg/kg reduced the plasma glucose level by 17.04% and 42.10%, respectively. A significant reduction in plasma insulin, plasma and hepatic total cholesterol (TC), triglycerides (TG) and free fatty acids (FFA) and a significant increase in liver glycogen were observed in treated diabetic rats. CONCLUSION: This study demonstrated the potential antidiabetic property of hexane extract of Symplocos cochinchinensis leaves on type 2 diabetes mellitus, thus justifying its traditional usage. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21182925/Antidiabetic_effect_of_Symplocos_cochinchinensis__Lour___S__Moore__in_type_2_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00894-9 DB - PRIME DP - Unbound Medicine ER -