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Pharmacologic treatment of spasticity in children.
Semin Pediatr Neurol. 2010 Dec; 17(4):261-7.SP

Abstract

Many clinicians frequently face the dilemma of whether and how to medically treat spasticity. When pharmacologic intervention is deemed appropriate, treatment decisions must first be based on accurate assessment using valid and reliable clinical instruments, and, importantly, specific, measurable, achievable, and realistic treatment goals should be delineated. For the treatment of localized or segmental spasticity, botulinum toxin (BoNT-A) is recommended as an effective and generally safe treatment. For more generalized spasticity, a number of useful oral agents and intrathecal baclofen are available, each with their positive and negative attributes. Fundamental knowledge of pharmacologic properties and toxicities of these medications is required for safe and appropriate use. To achieve optimum results, spasticity treatment should be part of an integrated therapeutic approach in which patients, caregivers, therapists, physicians, and surgeons have an open and clear communication about the overall rehabilitation process of the patient. This review summarizes the current pharmacologic approaches to spasticity treatment in children, critically evaluating published studies in the context of established evidence-based criteria.

Authors+Show Affiliations

Louisiana State University, New Orleans, LA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21183133

Citation

Tilton, Ann, et al. "Pharmacologic Treatment of Spasticity in Children." Seminars in Pediatric Neurology, vol. 17, no. 4, 2010, pp. 261-7.
Tilton A, Vargus-Adams J, Delgado MR. Pharmacologic treatment of spasticity in children. Semin Pediatr Neurol. 2010;17(4):261-7.
Tilton, A., Vargus-Adams, J., & Delgado, M. R. (2010). Pharmacologic treatment of spasticity in children. Seminars in Pediatric Neurology, 17(4), 261-7. https://doi.org/10.1016/j.spen.2010.10.009
Tilton A, Vargus-Adams J, Delgado MR. Pharmacologic Treatment of Spasticity in Children. Semin Pediatr Neurol. 2010;17(4):261-7. PubMed PMID: 21183133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic treatment of spasticity in children. AU - Tilton,Ann, AU - Vargus-Adams,Jilda, AU - Delgado,Mauricio R, PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/4/22/medline SP - 261 EP - 7 JF - Seminars in pediatric neurology JO - Semin Pediatr Neurol VL - 17 IS - 4 N2 - Many clinicians frequently face the dilemma of whether and how to medically treat spasticity. When pharmacologic intervention is deemed appropriate, treatment decisions must first be based on accurate assessment using valid and reliable clinical instruments, and, importantly, specific, measurable, achievable, and realistic treatment goals should be delineated. For the treatment of localized or segmental spasticity, botulinum toxin (BoNT-A) is recommended as an effective and generally safe treatment. For more generalized spasticity, a number of useful oral agents and intrathecal baclofen are available, each with their positive and negative attributes. Fundamental knowledge of pharmacologic properties and toxicities of these medications is required for safe and appropriate use. To achieve optimum results, spasticity treatment should be part of an integrated therapeutic approach in which patients, caregivers, therapists, physicians, and surgeons have an open and clear communication about the overall rehabilitation process of the patient. This review summarizes the current pharmacologic approaches to spasticity treatment in children, critically evaluating published studies in the context of established evidence-based criteria. SN - 1558-0776 UR - https://www.unboundmedicine.com/medline/citation/21183133/Pharmacologic_treatment_of_spasticity_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1071-9091(10)00112-9 DB - PRIME DP - Unbound Medicine ER -