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An analytical evaluation of eight on-site oral fluid drug screening devices using laboratory confirmation results from oral fluid.
Forensic Sci Int. 2011 May 20; 208(1-3):173-9.FS

Abstract

The performance of eight on-site oral fluid drug screening devices was studied in Belgium, Finland and the Netherlands as a part of the EU-project DRUID. The main objective of the study was to evaluate the reliability of the devices for testing drivers suspected of driving under the influence of drugs (DUID). The performance of the devices was assessed by their ability to detect substances using cut-offs which were set at sufficiently low levels to allow optimal detection of positive DUID cases. The devices were evaluated for the detection of amphetamine(s), cannabis, cocaine, opiates and benzodiazepines when the relevant test was incorporated. Methamphetamine, MDMA and PCP tests that were included in some devices were not evaluated since there were too few positive samples. The device results were compared with confirmation analysis results in oral fluid. The opiates tests appeared to perform relatively well with sensitivity results between 69 and 90%. Amphetamines and benzodiazepines tests had lower sensitivity, although the DrugWipe test evaluated was promising for amphetamine. In particular, it is evident that the cannabis and cocaine tests of the devices still lack sensitivity, although further testing of the cocaine tests is desirable due to the low prevalence and low concentrations encountered in this study.

Authors+Show Affiliations

Alcohol and Drug Analytics Unit, National Institute for Health and Welfare, Helsinki, Finland. thomas.blencowe@thl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21183299

Citation

Blencowe, Tom, et al. "An Analytical Evaluation of Eight On-site Oral Fluid Drug Screening Devices Using Laboratory Confirmation Results From Oral Fluid." Forensic Science International, vol. 208, no. 1-3, 2011, pp. 173-9.
Blencowe T, Pehrsson A, Lillsunde P, et al. An analytical evaluation of eight on-site oral fluid drug screening devices using laboratory confirmation results from oral fluid. Forensic Sci Int. 2011;208(1-3):173-9.
Blencowe, T., Pehrsson, A., Lillsunde, P., Vimpari, K., Houwing, S., Smink, B., Mathijssen, R., Van der Linden, T., Legrand, S. A., Pil, K., & Verstraete, A. (2011). An analytical evaluation of eight on-site oral fluid drug screening devices using laboratory confirmation results from oral fluid. Forensic Science International, 208(1-3), 173-9. https://doi.org/10.1016/j.forsciint.2010.11.026
Blencowe T, et al. An Analytical Evaluation of Eight On-site Oral Fluid Drug Screening Devices Using Laboratory Confirmation Results From Oral Fluid. Forensic Sci Int. 2011 May 20;208(1-3):173-9. PubMed PMID: 21183299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An analytical evaluation of eight on-site oral fluid drug screening devices using laboratory confirmation results from oral fluid. AU - Blencowe,Tom, AU - Pehrsson,Anna, AU - Lillsunde,Pirjo, AU - Vimpari,Kari, AU - Houwing,Sjoerd, AU - Smink,Beitske, AU - Mathijssen,René, AU - Van der Linden,Trudy, AU - Legrand,Sara-Ann, AU - Pil,Kristof, AU - Verstraete,Alain, Y1 - 2010/12/22/ PY - 2010/09/10/received PY - 2010/11/01/revised PY - 2010/11/26/accepted PY - 2010/12/25/entrez PY - 2010/12/25/pubmed PY - 2011/9/29/medline SP - 173 EP - 9 JF - Forensic science international JO - Forensic Sci Int VL - 208 IS - 1-3 N2 - The performance of eight on-site oral fluid drug screening devices was studied in Belgium, Finland and the Netherlands as a part of the EU-project DRUID. The main objective of the study was to evaluate the reliability of the devices for testing drivers suspected of driving under the influence of drugs (DUID). The performance of the devices was assessed by their ability to detect substances using cut-offs which were set at sufficiently low levels to allow optimal detection of positive DUID cases. The devices were evaluated for the detection of amphetamine(s), cannabis, cocaine, opiates and benzodiazepines when the relevant test was incorporated. Methamphetamine, MDMA and PCP tests that were included in some devices were not evaluated since there were too few positive samples. The device results were compared with confirmation analysis results in oral fluid. The opiates tests appeared to perform relatively well with sensitivity results between 69 and 90%. Amphetamines and benzodiazepines tests had lower sensitivity, although the DrugWipe test evaluated was promising for amphetamine. In particular, it is evident that the cannabis and cocaine tests of the devices still lack sensitivity, although further testing of the cocaine tests is desirable due to the low prevalence and low concentrations encountered in this study. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/21183299/An_analytical_evaluation_of_eight_on_site_oral_fluid_drug_screening_devices_using_laboratory_confirmation_results_from_oral_fluid_ DB - PRIME DP - Unbound Medicine ER -