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Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule.
Pediatr Infect Dis J. 2011 Jan; 30(1 Suppl):S25-9.PI

Abstract

INTRODUCTION

: Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed comparison of both vaccines in similar populations with high infant vaccination coverage.

METHODS

: Admission and rotavirus identification data from the major pediatric hospitals in 3 states (2 using RV5, 1 RV1), together with state-based hospitalization and vaccination data from Queensland (RV5) were analyzed for the years before, and up to 30 months following rotavirus vaccine introduction. Emergency encounters and short-stay unit admissions for gastroenteritis are also described.

RESULTS

: Rotavirus vaccine coverage in Australia is high, with 87% of infants receiving at least 1 dose. Hospital admissions for both rotavirus gastroenteritis and nonrotavirus-coded gastroenteritis were reduced following vaccine introduction in all states, not only for the age group eligible for NIP rotavirus vaccination, but also for children born prior. RV5 vaccine efficacy in Queensland has been estimated at 89.3%. Marked reductions in acute gastroenteritis emergency presentations and short-stay unit admissions have also been observed.

CONCLUSIONS

: Early evidence from the NIP in Australia has demonstrated high rotavirus coverage with both RV1 and RV5. The introduction of both vaccines has been associated with a marked reduction in gastroenteritis admissions, supportive of both direct vaccine protection, as well as with indirect herd protection.

Authors+Show Affiliations

Department of General Medicine and Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia; Paediatric Infectious Diseases Unit, Monash Children’s Hospital,Department of Paediatrics, Monash University, Melbourne, Victoria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21183837

Citation

Buttery, Jim P., et al. "Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule." The Pediatric Infectious Disease Journal, vol. 30, no. 1 Suppl, 2011, pp. S25-9.
Buttery JP, Lambert SB, Grimwood K, et al. Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule. Pediatr Infect Dis J. 2011;30(1 Suppl):S25-9.
Buttery, J. P., Lambert, S. B., Grimwood, K., Nissen, M. D., Field, E. J., Macartney, K. K., Akikusa, J. D., Kelly, J. J., & Kirkwood, C. D. (2011). Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule. The Pediatric Infectious Disease Journal, 30(1 Suppl), S25-9. https://doi.org/10.1097/INF.0b013e3181fefdee
Buttery JP, et al. Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule. Pediatr Infect Dis J. 2011;30(1 Suppl):S25-9. PubMed PMID: 21183837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule. AU - Buttery,Jim P, AU - Lambert,Stephen B, AU - Grimwood,Keith, AU - Nissen,Michael D, AU - Field,Emma J, AU - Macartney,Kristine K, AU - Akikusa,Jonathan D, AU - Kelly,Julian J, AU - Kirkwood,Carl D, PY - 2010/12/25/entrez PY - 2011/1/13/pubmed PY - 2011/4/5/medline SP - S25 EP - 9 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 30 IS - 1 Suppl N2 - INTRODUCTION: : Rotavirus vaccines were introduced into the funded Australian National Immunization Program (NIP) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/CSL) regimen. This allowed comparison of both vaccines in similar populations with high infant vaccination coverage. METHODS: : Admission and rotavirus identification data from the major pediatric hospitals in 3 states (2 using RV5, 1 RV1), together with state-based hospitalization and vaccination data from Queensland (RV5) were analyzed for the years before, and up to 30 months following rotavirus vaccine introduction. Emergency encounters and short-stay unit admissions for gastroenteritis are also described. RESULTS: : Rotavirus vaccine coverage in Australia is high, with 87% of infants receiving at least 1 dose. Hospital admissions for both rotavirus gastroenteritis and nonrotavirus-coded gastroenteritis were reduced following vaccine introduction in all states, not only for the age group eligible for NIP rotavirus vaccination, but also for children born prior. RV5 vaccine efficacy in Queensland has been estimated at 89.3%. Marked reductions in acute gastroenteritis emergency presentations and short-stay unit admissions have also been observed. CONCLUSIONS: : Early evidence from the NIP in Australia has demonstrated high rotavirus coverage with both RV1 and RV5. The introduction of both vaccines has been associated with a marked reduction in gastroenteritis admissions, supportive of both direct vaccine protection, as well as with indirect herd protection. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/21183837/Reduction_in_rotavirus_associated_acute_gastroenteritis_following_introduction_of_rotavirus_vaccine_into_Australia's_National_Childhood_vaccine_schedule_ L2 - http://dx.doi.org/10.1097/INF.0b013e3181fefdee DB - PRIME DP - Unbound Medicine ER -