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Use of calcium, folate, and vitamin D₃-fortified milk for 6 months improves nutritional status but not bone mass or turnover, in a group of Australian aged care residents.
J Nutr Elder 2009; 28(3):236-54JN

Abstract

In residential care, inadequate calcium and folate intakes and low serum vitamin D (25(OH)D) concentrations are common. We assessed whether daily provision of calcium, folate, and vitamin D₃-fortified milk for 6 months improved nutritional status (serum micronutrients), bone quality (heel ultrasound), bone turnover markers (parathyroid hormone, C-terminal collagen I telopeptide, terminal propeptide of type I procollagen), and/or muscle strength and mobility in a group of Australian aged care residents. One hundred and seven residents completed the study (mean (SD) age: 79.9 (10.1) years; body weight: 68.4 (15.4) kg). The median (inter-quartile range) volume of fortified milk consumed was 160 (149) ml/day. At the end of the study, the median daily vitamin D intake increased to 10.4 (8.7) μg (P < .001), which is 70% of the adequate intake (15 μg); and calcium density (mg/MJ) was higher over the study period compared with baseline (161 ± 5 mg/MJ vs. 142 ± 4 mg/MJ, P < .001). Serum 25(OH)D concentrations increased by 23 ± 2 nmol/L (83 (107)%, P < .001), yet remained in the insufficient range (mean 45 ± 2 nmol/L). Consumption of greater than the median intake of milk (160 ml/day) (n = 54, 50%) increased serum 25(OH)D levels into the adequate range (53 ± 2 nmol/L) and reduced serum parathyroid hormone by 24% (P = .045). There was no effect on bone quality, bone turnover markers, muscle strength, or mobility. Consumption of fortified milk increased dietary vitamin D intake and raised serum 25(OH)D concentrations, but not to the level thought to reduce fracture risk. If calcium-fortified milk also was used in cooking and milk drinks, this approach could allow residents to achieve a dietary calcium intake close to recommended levels. A vitamin D supplement would be recommended to ensure adequate vitamin D status for all residents.

Authors+Show Affiliations

School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21184368

Citation

Grieger, Jessica A., and Caryl A. Nowson. "Use of Calcium, Folate, and Vitamin D₃-fortified Milk for 6 Months Improves Nutritional Status but Not Bone Mass or Turnover, in a Group of Australian Aged Care Residents." Journal of Nutrition for the Elderly, vol. 28, no. 3, 2009, pp. 236-54.
Grieger JA, Nowson CA. Use of calcium, folate, and vitamin D₃-fortified milk for 6 months improves nutritional status but not bone mass or turnover, in a group of Australian aged care residents. J Nutr Elder. 2009;28(3):236-54.
Grieger, J. A., & Nowson, C. A. (2009). Use of calcium, folate, and vitamin D₃-fortified milk for 6 months improves nutritional status but not bone mass or turnover, in a group of Australian aged care residents. Journal of Nutrition for the Elderly, 28(3), pp. 236-54. doi:10.1080/01639360903140130.
Grieger JA, Nowson CA. Use of Calcium, Folate, and Vitamin D₃-fortified Milk for 6 Months Improves Nutritional Status but Not Bone Mass or Turnover, in a Group of Australian Aged Care Residents. J Nutr Elder. 2009;28(3):236-54. PubMed PMID: 21184368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of calcium, folate, and vitamin D₃-fortified milk for 6 months improves nutritional status but not bone mass or turnover, in a group of Australian aged care residents. AU - Grieger,Jessica A, AU - Nowson,Caryl A, PY - 2010/12/25/entrez PY - 2009/7/1/pubmed PY - 2011/2/2/medline SP - 236 EP - 54 JF - Journal of nutrition for the elderly JO - J Nutr Elder VL - 28 IS - 3 N2 - In residential care, inadequate calcium and folate intakes and low serum vitamin D (25(OH)D) concentrations are common. We assessed whether daily provision of calcium, folate, and vitamin D₃-fortified milk for 6 months improved nutritional status (serum micronutrients), bone quality (heel ultrasound), bone turnover markers (parathyroid hormone, C-terminal collagen I telopeptide, terminal propeptide of type I procollagen), and/or muscle strength and mobility in a group of Australian aged care residents. One hundred and seven residents completed the study (mean (SD) age: 79.9 (10.1) years; body weight: 68.4 (15.4) kg). The median (inter-quartile range) volume of fortified milk consumed was 160 (149) ml/day. At the end of the study, the median daily vitamin D intake increased to 10.4 (8.7) μg (P < .001), which is 70% of the adequate intake (15 μg); and calcium density (mg/MJ) was higher over the study period compared with baseline (161 ± 5 mg/MJ vs. 142 ± 4 mg/MJ, P < .001). Serum 25(OH)D concentrations increased by 23 ± 2 nmol/L (83 (107)%, P < .001), yet remained in the insufficient range (mean 45 ± 2 nmol/L). Consumption of greater than the median intake of milk (160 ml/day) (n = 54, 50%) increased serum 25(OH)D levels into the adequate range (53 ± 2 nmol/L) and reduced serum parathyroid hormone by 24% (P = .045). There was no effect on bone quality, bone turnover markers, muscle strength, or mobility. Consumption of fortified milk increased dietary vitamin D intake and raised serum 25(OH)D concentrations, but not to the level thought to reduce fracture risk. If calcium-fortified milk also was used in cooking and milk drinks, this approach could allow residents to achieve a dietary calcium intake close to recommended levels. A vitamin D supplement would be recommended to ensure adequate vitamin D status for all residents. SN - 1540-8566 UR - https://www.unboundmedicine.com/medline/citation/21184368/Use_of_calcium_folate_and_vitamin_D₃_fortified_milk_for_6_months_improves_nutritional_status_but_not_bone_mass_or_turnover_in_a_group_of_Australian_aged_care_residents_ L2 - https://medlineplus.gov/calcium.html DB - PRIME DP - Unbound Medicine ER -