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Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice.
J Ethnopharmacol. 2011 Mar 24; 134(2):504-9.JE

Abstract

ETHNOPHARMACOLOGICAL SIGNIFICANCE

The Cordyceps species are insect-borne mushrooms that have been ethnopharmacologically used for skin diseases such as eczema and dermatitis.

AIM OF THE STUDY

In this study, we investigated the curative effects of the butanol fraction (CBBF) of Cordyceps bassiana on atopic dermatitis.

MATERIALS AND METHODS

Dermatitis was induced by repeated application of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice. After a topical application of CBBF on the skin lesions, the dermatitis score, epidermal thickness, mast cell number, and interleukin (IL)-4 and interferon (IFN)-γ, as well as the levels of histamine and immunoglobulin E (IgE) in the serum, were measured. Moreover, effect of CBBF on histamine release was examined using RBL-2H3 under stimulation with 2,4-dinitrophenylated bovine serum albumin (DNP-BSA).

RESULTS

CBBF inhibited atopic dermatitis symptoms and signs in the DNFB-treated NC/Nga mice. The suppressive activity of topically applied CBBF may be due to the dose-dependent blockade of a series of immunopathological events, including the release of histamine, the production of IgE, and the secretion of IL-4 and IFN-γ. However, this extract did not directly suppress the degranulation process, assessed by measuring β-hexosaminidase release.

CONCLUSIONS

Our results suggest that CBBF can be applied as an effective herbal remedy to treat atopic dermatitis.

Authors+Show Affiliations

Department of Physiology, College of Medicine, Hallym University, 39 Hallymdaehak-gil, Chuncheon 200-702, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21184821

Citation

Wu, Guang, et al. "Inhibition of 2,4-dinitrofluorobenzene-induced Atopic Dermatitis By Topical Application of the Butanol Extract of Cordyceps Bassiana in NC/Nga Mice." Journal of Ethnopharmacology, vol. 134, no. 2, 2011, pp. 504-9.
Wu G, Li L, Sung GH, et al. Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice. J Ethnopharmacol. 2011;134(2):504-9.
Wu, G., Li, L., Sung, G. H., Kim, T. W., Byeon, S. E., Cho, J. Y., Park, C. W., & Park, H. J. (2011). Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice. Journal of Ethnopharmacology, 134(2), 504-9. https://doi.org/10.1016/j.jep.2010.12.012
Wu G, et al. Inhibition of 2,4-dinitrofluorobenzene-induced Atopic Dermatitis By Topical Application of the Butanol Extract of Cordyceps Bassiana in NC/Nga Mice. J Ethnopharmacol. 2011 Mar 24;134(2):504-9. PubMed PMID: 21184821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice. AU - Wu,Guang, AU - Li,Lan, AU - Sung,Gi Ho, AU - Kim,Tae Woong, AU - Byeon,Se Eun, AU - Cho,Jae Youl, AU - Park,Chun Wook, AU - Park,Hyoung Jin, Y1 - 2010/12/22/ PY - 2010/07/13/received PY - 2010/11/22/revised PY - 2010/12/08/accepted PY - 2010/12/28/entrez PY - 2010/12/28/pubmed PY - 2011/11/8/medline SP - 504 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 134 IS - 2 N2 - ETHNOPHARMACOLOGICAL SIGNIFICANCE: The Cordyceps species are insect-borne mushrooms that have been ethnopharmacologically used for skin diseases such as eczema and dermatitis. AIM OF THE STUDY: In this study, we investigated the curative effects of the butanol fraction (CBBF) of Cordyceps bassiana on atopic dermatitis. MATERIALS AND METHODS: Dermatitis was induced by repeated application of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice. After a topical application of CBBF on the skin lesions, the dermatitis score, epidermal thickness, mast cell number, and interleukin (IL)-4 and interferon (IFN)-γ, as well as the levels of histamine and immunoglobulin E (IgE) in the serum, were measured. Moreover, effect of CBBF on histamine release was examined using RBL-2H3 under stimulation with 2,4-dinitrophenylated bovine serum albumin (DNP-BSA). RESULTS: CBBF inhibited atopic dermatitis symptoms and signs in the DNFB-treated NC/Nga mice. The suppressive activity of topically applied CBBF may be due to the dose-dependent blockade of a series of immunopathological events, including the release of histamine, the production of IgE, and the secretion of IL-4 and IFN-γ. However, this extract did not directly suppress the degranulation process, assessed by measuring β-hexosaminidase release. CONCLUSIONS: Our results suggest that CBBF can be applied as an effective herbal remedy to treat atopic dermatitis. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21184821/Inhibition_of_24_dinitrofluorobenzene_induced_atopic_dermatitis_by_topical_application_of_the_butanol_extract_of_Cordyceps_bassiana_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00871-8 DB - PRIME DP - Unbound Medicine ER -