Tags

Type your tag names separated by a space and hit enter

Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder.
J Child Adolesc Psychopharmacol 2010; 20(6):495-502JC

Abstract

INTRODUCTION

Iron deficiency (ID) has been associated with attention and behavioral problems, in general, and with attention-deficit/hyperactivity disorder (ADHD), in particular. The study aim was to explore whether iron stores, as reflected by serum ferritin concentration, predicted response to psychostimulants.

METHODS

Six- to 14-year-old children with ADHD enrolled in a multiphase, double-blind, randomized, placebo-controlled trial investigating zinc supplementation in treating ADHD and optimizing response to psychostimulants. The Swanson, Nolan, and Pelham (SNAP) ADHD rating scale was the primary clinical instrument. Serum ferritin concentration was obtained at baseline and 8 weeks later. Partial correlations, adjusting for age and sex, were computed.

RESULTS

Fifty-two participants (83% males) had a mean age of 10 years. Their ADHD symptoms were moderately severe at baseline (SNAP item mean = 2.1). Their mean ferritin concentration was 18.4 ng/mL, with 23% of the participants having a level below 7, the assay-defined threshold for ID. Serum ferritin was inversely correlated with baseline inattention, hyperactivity/impulsivity, and total ADHD symptom scores (Partial Spearman's r = -0.31, p = 0.04; r = -0.42, p < 0.006; and r = -0.43, p < 0.004, respectively) and with the weight-adjusted dose of amphetamine used to optimize clinical response (Partial Spearman's r = -0.45, p < 0.007). Psychotropic-treatment history moderated some, but not all, of these associations, with previously medicated children showing a stronger association between ferritin concentration and ADHD symptom severity.

CONCLUSION

These findings add to the growing literature implicating ID in ADHD. The prediction of amphetamine optimal dose by ferritin concentration suggests that iron supplementation should be investigated as a potential intervention to optimize response to psychostimulants at a lower dose in individuals with low iron stores and ADHD.

Authors+Show Affiliations

Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. chadi-calarge@uiowa.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21186968

Citation

Calarge, Chadi, et al. "Serum Ferritin and Amphetamine Response in Youth With Attention-deficit/hyperactivity Disorder." Journal of Child and Adolescent Psychopharmacology, vol. 20, no. 6, 2010, pp. 495-502.
Calarge C, Farmer C, DiSilvestro R, et al. Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2010;20(6):495-502.
Calarge, C., Farmer, C., DiSilvestro, R., & Arnold, L. E. (2010). Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 20(6), pp. 495-502. doi:10.1089/cap.2010.0053.
Calarge C, et al. Serum Ferritin and Amphetamine Response in Youth With Attention-deficit/hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2010;20(6):495-502. PubMed PMID: 21186968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder. AU - Calarge,Chadi, AU - Farmer,Cristan, AU - DiSilvestro,Robert, AU - Arnold,L Eugene, PY - 2010/12/29/entrez PY - 2010/12/29/pubmed PY - 2011/4/13/medline SP - 495 EP - 502 JF - Journal of child and adolescent psychopharmacology JO - J Child Adolesc Psychopharmacol VL - 20 IS - 6 N2 - INTRODUCTION: Iron deficiency (ID) has been associated with attention and behavioral problems, in general, and with attention-deficit/hyperactivity disorder (ADHD), in particular. The study aim was to explore whether iron stores, as reflected by serum ferritin concentration, predicted response to psychostimulants. METHODS: Six- to 14-year-old children with ADHD enrolled in a multiphase, double-blind, randomized, placebo-controlled trial investigating zinc supplementation in treating ADHD and optimizing response to psychostimulants. The Swanson, Nolan, and Pelham (SNAP) ADHD rating scale was the primary clinical instrument. Serum ferritin concentration was obtained at baseline and 8 weeks later. Partial correlations, adjusting for age and sex, were computed. RESULTS: Fifty-two participants (83% males) had a mean age of 10 years. Their ADHD symptoms were moderately severe at baseline (SNAP item mean = 2.1). Their mean ferritin concentration was 18.4 ng/mL, with 23% of the participants having a level below 7, the assay-defined threshold for ID. Serum ferritin was inversely correlated with baseline inattention, hyperactivity/impulsivity, and total ADHD symptom scores (Partial Spearman's r = -0.31, p = 0.04; r = -0.42, p < 0.006; and r = -0.43, p < 0.004, respectively) and with the weight-adjusted dose of amphetamine used to optimize clinical response (Partial Spearman's r = -0.45, p < 0.007). Psychotropic-treatment history moderated some, but not all, of these associations, with previously medicated children showing a stronger association between ferritin concentration and ADHD symptom severity. CONCLUSION: These findings add to the growing literature implicating ID in ADHD. The prediction of amphetamine optimal dose by ferritin concentration suggests that iron supplementation should be investigated as a potential intervention to optimize response to psychostimulants at a lower dose in individuals with low iron stores and ADHD. SN - 1557-8992 UR - https://www.unboundmedicine.com/medline/citation/21186968/Serum_ferritin_and_amphetamine_response_in_youth_with_attention_deficit/hyperactivity_disorder_ L2 - https://www.liebertpub.com/doi/full/10.1089/cap.2010.0053?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -